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  4. Monoclonal Antibodies Recombinant Antibodies
  5. MBD1 Antibody (YA2441)

MBD1 Antibody (YA2441) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MBD1.

For research use only. We do not sell to patients.

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20 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

MBD1 Antibody (YA2441) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MBD1.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molecular Weight
Predicted band size: 67 kDa;
Observed band size: 67 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human MBD1 aa550-605/605.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:50-1:100
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:50-1:200
IP
IP: Immunoprecipitation
1:20
Sensitivity Endogenous Purity Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters
Subcellular Localization：Nucleus; Nucleus matrix; Nucleus speckle; Chromosome
Expression：
Tissue_specificity:Widely expressed

Induction:Up-regulated by interferon
Isoforms & Post-Translational Modification：Q9UIS9 has 11 isomers: Q9UIS9-1: 66607 Da (predicted); Q9UIS9-2: 64677 Da (predicted); Q9UIS9-4: 55167 Da (predicted); Q9UIS9-5: 61265 Da (predicted); Q9UIS9-6: 60848 Da (predicted); Q9UIS9-7: 60001 Da (predicted); Q9UIS9-8: 59158 Da (predicted); Q9UIS9-9: 69617 Da (predicted); Q9UIS9-10: 62639 Da (predicted); Q9UIS9-11: 58752 Da (predicted); Q9UIS9-12: 72126 Da (predicted).
Sumoylated, sumoylation may increase interaction with ATF7IP
Subunit：Interacts with OASL, ATF7IP, ATF7IP2 and BAHD1 (PubMed:12665582, PubMed:14728690, PubMed:15691849, PubMed:16757475, PubMed:19666599). Binds CHAF1A and the SUV39H1-CBX5 complex via the MBD domain (PubMed:12697822, PubMed:12711603). Binds MGP via the TRD domain (PubMed:14555760). May be part of the MeCP1 complex (PubMed:9207790)
Database

Entrez Gene: 4152 Human

SwissProt: Q9UIS9 Human

OMIM: 156535 Human

Research Field

Epigenetics and Nuclear Signaling
Synonyms
CXXC 3; Mbd1; MECP1 COMPLEX; PCM1; RFT
Documentation
User Guide for Antibodies (1077 KB)

MBD1 Antibody (YA2441) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MBD1 Antibody (YA2441)
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HY-P82696
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