MICAL1 Antibody (YA8441)
(Synonyms: MICAL; MICAL-1; NICAL)MICAL1 Antibody (YA8441) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MICAL1.
-
Host:
Mouse
-
Isotype:
IgG1
-
Application:
IHC-P, ICC/IF, FC
-
Reactivity :
Human
-
Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
|
|---|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 | 1:100 |
Product Details
MICAL1 Antibody (YA8441) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MICAL1.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman
-
Calculated Molecular Weight Predicted band size: 117.7 kDa
Full length human recombinant protein of human MICAL1 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
-
Appearance
Liquid
-
Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
MICAL1 is a Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking. Promotes endosomal tubule extension by associating with RAB8 (RAB8A or RAB8B), RAB10 and GRAF (GRAF1/ARHGAP26 or GRAF2/ARHGAP10) on the endosomal membrane which may connect GRAFs to Rabs, thereby participating in neosynthesized Rab8-Rab10-Rab11-dependent protein export[1][2][3][4].
-
Subcellular Localization
Cytoplasm,Cytoplasm, cytoskeleton,Endosome membrane,Midbody
-
Expression
Tissue_Specificity: Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells -
Isoforms & Post-Translational Modification
Q8TDZ2 has four isomers: Q8TDZ2-1: 117875 Da (predicted); Q8TDZ2-2: 108552 Da (predicted); Q8TDZ2-3: 37715 Da (predicted); Q8TDZ2-4: 119821 Da (predicted).
-
Subunit
Interacts with STK38 and STK38L (By similarity)
-
SwissProt ID
-
Synonyms
MICAL; MICAL-1; NICAL
Documentation
Powered by Bioz
