MPP5 Antibody (YA8308)

Cat. No.: HY-P88624: Ficha de datos User Guide for Antibodies
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MPP5 Antibody (YA8308) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MPP5.

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Tamaño	Precio	Stock
20 μL		Pide un presupuesto y un plazo de entrega
50 μL		Pide un presupuesto y un plazo de entrega
100 μL		Pide un presupuesto y un plazo de entrega

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn
Referencias

Descripciòn

MPP5 Antibody (YA8308) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MPP5.

Host

Mouse

Clonality

Monoclonal

Peso molecular

Predicted band size: 77.1 kDa

Species Reactivity

Human, Dog, Rat, Mouse

SwissProt ID

Q8N3R9

Immunogen

Full length human recombinant protein of human MPP5 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
FC FC: Flow Cytometry	1:100

Sensitivity	Endogenous	Pureza	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG2a

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:16678097, PubMed:25385611). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (PubMed:27466317). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). Plays a role in the T-cell receptor-mediated activation of NF-kappa-B (PubMed:21479189). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity)|(Microbial infection) Acts as an interaction partner for human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity

Subcellular Localization：Golgi apparatus,Cell membrane,Endomembrane system,Cell junction, tight junction,Cell junction, adherens junction,Cell projection, axon,Perikaryon,Apical cell membrane,Endoplasmic reticulum-Golgi intermediate compartment,Golgi apparatus

Expression：
Tissue_Specificity: Expressed at the outer limiting membrane in the retina (at protein level) (PubMed:15558731, PubMed:15914641, PubMed:16519681, PubMed:17584769). Expressed in T lymphocytes (at protein level) (PubMed:21479189). Expressed in the kidney (at protein level) (PubMed:17584769)

Isoforms & Post-Translational Modification：Q8N3R9 has two isomers: Q8N3R9-1: 77294 Da (predicted); Q8N3R9-2: 73421 Da (predicted).

Subunit：Heterodimer with MPP1 (PubMed:17584769)

Synonyms

PALS1

Documentación

User Guide for Antibodies (1077 KB)

Referencias

[1]. /biology-dictionary/l02-cell.html [Content Brief]