MRP4 Antibody (YA1166)(PBS only)
(Synonyms: MRP4; MOATB; MOAT-B; EST170205)MRP4 Antibody (YA1166) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MRP4.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:100-1:200 |
Product Details
MRP4 Antibody (YA1166) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MRP4.
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Host Rabbit
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 150 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 150 kDa
Recombinant protein of human MRP4
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MRP4 is an ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Confers resistance to anticancer agents such as methotrexate[1][2][3][4][5][6][7][8][9][10][11][12][13].
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Subcellular Localization
Basolateral cell membrane; Multi-pass membrane protein; Apical cell membrane; Multi-pass membrane protein
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Expression
Tissue_specificity:It is widely expressed, with particularly high levels in the prostate, but is almost undetectable in the liver. (Hepatocyte sinusoidal membrane) -
Isoforms & Post-Translational Modification
O15439 has 4 isomers: O15439-1: 149527 Da (predicted); O15439-2: 144201 Da (predicted); O15439-3: 96841 Da (predicted); O15439-4: 88138 Da (predicted).
N-glycosylated; leading to substrate-selective effects on its transport activity -
Subunit
Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); this interaction accelerates MRP4 internalization
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SwissProt ID
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Synonyms
MRP4; MOATB; MOAT-B; EST170205
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Research Field
Signal Transduction
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