ABCC4 - ATP binding cassette subfamily C member 4 Gene

Also Known as MRP4; MOATB; MOAT-B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10257

About ABCC4

Cytogenetic location: 13q32.1 Genomic coordinates (GRCh38): 13:95,019,835-95,301,451 (from NCBI)

This gene has 16 transcripts (splice variants), 461 orthologues and 11 paralogues. Broad expression in prostate (RPKM 22.4), urinary bladder (RPKM 9.3) and 16 other tissues.

Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

ABCC4 Products (4)

mRNA	Protein	Name
NM_001105515.3	NP_001098985.1	ATP-binding cassette sub-family C member 4 isoform 2
NM_001301829.2	NP_001288758.1	ATP-binding cassette sub-family C member 4 isoform 3
NM_001301830.2	NP_001288759.1	ATP-binding cassette sub-family C member 4 isoform 4
NM_005845.5	NP_005836.2	ATP-binding cassette sub-family C member 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ABC-type bile acid transporter activity	IMP IMP: Inferred from mutant phenotype	16282361	GOA
enables ABC-type glutathione S-conjugate transporter activity	IDA IDA: Inferred from direct assay	17959747	GOA
enables ATPase-coupled transmembrane transporter activity	IDA IDA: Inferred from direct assay	15364914	GOA
enables efflux transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	25986174	GOA
enables glutathione transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	11856762	GOA
enables guanine nucleotide transmembrane transporter activity	IDA IDA: Inferred from direct assay	15454390	GOA
enables prostaglandin transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	15364914	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22411990	GOA
enables purine nucleotide transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	25986174	GOA
enables urate transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	15454390	GOA
enables xenobiotic transmembrane transporter activity	IDA IDA: Inferred from direct assay	11856762	GOA
enables xenobiotic transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	25986174	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in bile acid and bile salt transport	IMP IMP: Inferred from mutant phenotype	16282361	GOA
involved in cAMP transport	IDA IDA: Inferred from direct assay	11856762	GOA
involved in cAMP transport	IMP IMP: Inferred from mutant phenotype	25986174	GOA
acts upstream of or within cilium assembly	IMP IMP: Inferred from mutant phenotype	25173977	GOA
involved in export across plasma membrane	IMP IMP: Inferred from mutant phenotype	25986174	GOA
involved in leukotriene transport	IDA IDA: Inferred from direct assay	17959747	GOA
acts upstream of or within prostaglandin secretion	IDA IDA: Inferred from direct assay	25173977	GOA
involved in prostaglandin transport	IMP IMP: Inferred from mutant phenotype	15364914	GOA
involved in urate transport	IMP IMP: Inferred from mutant phenotype	15454390	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	11856762	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	24130369	GOA
located in membrane	IDA IDA: Inferred from direct assay	15297306	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15297306	GOA
located in platelet dense granule membrane	IDA IDA: Inferred from direct assay	15297306	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABCC4 Protein Structure

ABC_membrane

ABC_tran

ABC_membrane

ABC_tran

0
300
600
900
1200
1325 a.a.

Protein Preferred Names	Protein Names
ATP-binding cassette sub-family C member 4	MRP/cMOAT-related ABC transporter

ABCC4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81421	MRP4 Antibody (YA1166)	IHC-P	Human
HY-P81421A	MRP4 Antibody (YA1166)(PBS only)	IHC-P	Human
HY-P83833	MRP4 Antibody (YA3530)	IHC-P, FC, ELISA	Human
HY-P83833A	MRP4 Antibody (YA3530)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Cholestasis	Obstruction Of Bile Duct Bile Duct Obstruction Bile Occlusion Extrahepatic Biliary Obstruction Extrahepatic Bile Duct Obstruction Bile Stasis Biliary Stasis Obstructive Hyperbilirubinemia Obstructed Jaundice Bile Duct Obstructed Bile Ductal Obstruction Biliary Duct Obstruction Obstructed Bile Ductal Obstructed Biliary Duct Obstructed Biliary Ductal Jaundice Regurgitation Obstructive Jaundice Cholestatic Jaundice Cholestatic Jaundice Syndrome
Dubin-Johnson Syndrome	DJS Chronic Idiopathic Jaundice Jaundice, Chronic Idiopathic Hyperbilirubinemia, Dubin-Johnson Type Hyperbilirubinemia Ii Hyperbilirubinemia Type 2 Conjugated Hyperbilirubinemia Dubin-Sprinz Disease Sprinz-Nelson Syndrome Hblrdj Dubin Johnson Syndrome Hyperbilirubinemia 2 Black Liver-Jaundice Syndrome Chronic Idiopathic Jaundice With Pigmented Liver Dubin-Sprinz Syndrome Hyperbilirubinaemia Type 2 Djs - [Dubin-Johnson Syndrome]
Hyperuricemia	Blood Urate Raized Uricacidemia
Fanconi-Like Syndrome	Fanconi Like Syndrome
Thiopurines, Poor Metabolism Of, 1	Thiopurine S-Methyltransferase Deficiency Tpmt Deficiency Thiopurine Methyltransferase Deficiency Thiopurine S Methyltranferase Deficiency THPM1 Tpmtd Poor Metabolism Of Thiopurines-1 6-Mercaptopurine Sensitivity Thiopurines, Poor Metabolism Of Poor Metabolism Of Thiopurines
Cholestasis, Benign Recurrent Intrahepatic, 1	Benign Recurrent Intrahepatic Cholestasis BRIC1 Summerskill Syndrome Bric Summerskill-Walshe-Tygstrup Syndrome Cholestasis, Benign Recurrent Intrahepatic Benign Recurrent Intrahepatic Cholestasis 1 Benign Recurrent Intrahepatic Cholestasis Type 1 Bric Type 1 Low Gamma-Gt Familial Intrahepatic Cholestasis Recurrent Familial Intrahepatic Cholestasis Cholestasis, Benign Recurrent Intrahepatic 1 Mild Atp8b1 Deficiency Recurrent Familial Intrahepatic Cholestasis 1 Abcb11-Related Intrahepatic Cholestasis Atp8b1-Related Intrahepatic Cholestasis Cholestasis, Intrahepatic, Recurrent, Benign, Type 1 Progressive Intrahepatic Cholestasis Cholestasis, Progressive Familial Intrahepatic 3 Bric - [Benign Recurrent Intrahepatic Cholestasis]
Cholestasis, Progressive Familial Intrahepatic, 2	PFIC2 Cholestasis, Progressive Familial Intrahepatic 2 Progressive Familial Intrahepatic Cholestasis Type 2 Progressive Familial Intrahepatic Cholestasis 2 Bsep Deficiency Recurrent Familial Intrahepatic Cholestasis 2 Benign Recurrent Intrahepatic Cholestasis 2 Severe Abcb11 Deficiency Bric2 Cholestasis, Benign Recurrent Intrahepatic 2 Mild Abcb11 Deficiency Cholestasis, Intrahepatic, Familial, Progressive, Type 2
Intrahepatic Cholestasis Of Pregnancy	Recurrent Intrahepatic Cholestasis Of Pregnancy Gravidic Intrahepatic Cholestasis Pregnancy-Related Cholestasis Icp Pregnancy Related Cholestasis Cholestasis, Intrahepatic Of Pregnancy Familial Intrahepatic Cholestasis Of Pregnancy Familial Recurrent Intrahepatic Cholestasis Of Pregnancy Ricp Obstetric Cholestasis
Progressive Familial Intrahepatic Cholestasis	Abcb4-Related Intrahepatic Cholestasis Cholestasis, Progressive Familial Intrahepatic Pfic Byler Disease Abcb11-Related Intrahepatic Cholestasis Atp8b1-Related Intrahepatic Cholestasis Bsep Deficiency Byler Disease Byler Syndrome Fic1 Deficiency Low Γ-Gt Familial Intrahepatic Cholestasis Mdr3 Deficiency Pfic Cholestasis, Intrahepatic, Familial, Progressive Pfic - [Progressive Familial Intrahepatic Cholestasis]
Cholestasis, Progressive Familial Intrahepatic, 3	PFIC3 Cholestasis, Progressive Familial Intrahepatic 3 Mdr3 Deficiency Progressive Familial Intrahepatic Cholestasis Type 3 Progressive Familial Intrahepatic Cholestasis 3 Progressive Familial Intrahepatic Cholestasis With Elevated Serum Gamma-Glutamyltransferase Cholestasis, Progressive Familial Intrahepatic, With Elevated Serum Gamma-Glutamyltransferase Progressive Familial Intrahepatic Cholestasis With Elevated Serum Gama-Glutamyltransferase Cholestasis, Intrahepatic, Familial, Progressive, Type 3
Bilirubin Metabolic Disorder	Hyperbilirubinemia Hereditary Hyperbilirubinemia Hyperbilirubinemia, Hereditary Hyperbilirubinaemia
Fanconi Syndrome	Infantile Nephropathic Cystinosis Adult Fanconi Syndrome Congenital Fanconi Syndrome De Toni-Fanconi Syndrome Fanconi-De Toni Syndrome Lignac-Fanconi Syndrome Fanconi Renotubular Syndrome Primary Fanconi Renotubular Syndrome De Toni-Debre-Fanconi Syndrome Adult Fanconi Anemia Detoni Fanconi Syndrome Fanconi-De-Toni Syndrome Primary Fanconi Syndrome Detoni-Debre-Fanconi Syndrome Primary Fanconi Renal Syndrome Fanconi Anemia Cystinosis, Infantile Nephropathic Fanconi-Bickel Syndrome Renal Fanconi Syndrome Lowe-Bickel Syndrome
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19989A	MK-571 sodium		99.75%	Unkown
HY-129764	Prostaglandin F3α	Substrate	/	Unkown
HY-RS00063	ABCC4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20355	Abcc4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26864	Abcc4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ABCC4	MGD	MGI:2443111
Canis familiaris	ABCC4	VGNC	VGNC:37441
Macaca mulatta	ABCC4	VGNC	VGNC:69573
Felis catus	ABCC4	VGNC	VGNC:67718
Rattus norvegicus	ABCC4	RGD	RGD:620266
Others	ABCC4	NCBI