LYRIC/AEG1 Antibody (YA4978)

Cat. No.: HY-P85286: Data Sheet User Guide for Antibodies
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LYRIC/AEG1 Antibody (YA4978) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to LYRIC/AEG1.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

LYRIC/AEG1 Antibody (YA4978) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to LYRIC/AEG1.

Host

Rabbit

Clonality

Monoclonal,Recombinant

Molecular Weight

Predicted band size: 64 kDa;

Observed band size: 75 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q86UE4

Gene ID

92140 [NCBI]

Immunogen

A synthesized peptide derived from human MTDH. The exact sequence is proprietary to MCE.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-200
IHC-F IHC-F: Immunohistochemistry-Frozen	1:50-200
IF-Tissue IF-Tissue: Immunofluorescence-Tissue	1:50-200

Sensitivity	Endogenous	Purity	affinity purified by Protein A
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance

Subcellular Localization：Endoplasmic reticulum membrane; Single-pass membrane protein; Nucleus membrane; Single-pass membrane protein; Cell junction, tight junction; Nucleus, nucleolus; Cytoplasm, perinuclear region

Expression：
Tissue_specificity:This gene is widely expressed in muscle-based organs (such as skeletal muscle, heart, tongue, and small intestine) and endocrine glands (such as the thyroid and adrenal glands) , with the highest expression levels. It is overexpressed in a variety of cancers, including breast cancer, brain cancer, prostate cancer, melanoma, and glioblastoma multiforme.

Induction:By TNF (at protein level) . By HIV-1 infection of primary fetal astrocytes

Subunit：Interacts with BCCIP, CREBBP/CBP and RELA/p65

Synonyms

MTDH; AEG1; LYRIC; Protein LYRIC; 3D3/LYRIC; Astrocyte elevated gene-1 protein; AEG-1; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein

Documentation

User Guide for Antibodies (1077 KB)