LYRIC/AEG1 Antibody (YA4978)
(Synonyms: MTDH; AEG1; LYRIC; Protein LYRIC; 3D3/LYRIC; Astrocyte elevated gene-1 protein; AEG-1; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein)LYRIC/AEG1 Antibody (YA4978) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to LYRIC/AEG1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB; IHC-P; IHC-F; IF-Tissue
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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|---|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:50-200 | 1:50-200 | 1:50-200 |
Product Details
LYRIC/AEG1 Antibody (YA4978) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to LYRIC/AEG1.
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Host Rabbit
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 75 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 64 kDa
A synthesized peptide derived from human MTDH. The exact sequence is proprietary to MCE.
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
LYRIC/AEG1 is a Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance
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Subcellular Localization
Endoplasmic reticulum membrane; Single-pass membrane protein; Nucleus membrane; Single-pass membrane protein; Cell junction, tight junction; Nucleus, nucleolus; Cytoplasm, perinuclear region
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Expression
Tissue_specificity:This gene is widely expressed in muscle-based organs (such as skeletal muscle, heart, tongue, and small intestine) and endocrine glands (such as the thyroid and adrenal glands) , with the highest expression levels. It is overexpressed in a variety of cancers, including breast cancer, brain cancer, prostate cancer, melanoma, and glioblastoma multiforme.
Induction:By TNF (at protein level) . By HIV-1 infection of primary fetal astrocytes -
Subunit
Interacts with BCCIP, CREBBP/CBP and RELA/p65
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SwissProt ID
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Synonyms
MTDH; AEG1; LYRIC; Protein LYRIC; 3D3/LYRIC; Astrocyte elevated gene-1 protein; AEG-1; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein
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