MTDH - metadherin Gene

Also Known as 3D3; AEG1; AEG-1; LYRIC; LYRIC/3D3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 92140

About MTDH

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:97,644,184-97,730,260 (from NCBI)

This gene has 6 transcripts (splice variants), 129 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 24.7), bone marrow (RPKM 21.0) and 25 other tissues.

Summary

Enables NF-kappaB binding activity; double-stranded RNA binding activity; and transcription coactivator activity. Involved in several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of intracellular signal transduction; and regulation of transcription, DNA-templated. Located in endoplasmic reticulum; nuclear lumen; and perinuclear region of cytoplasm. Implicated in hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

MTDH Products (5)

mRNA Protein Name
NM_001363136.1 NP_001350065.1 protein LYRIC isoform 2
NM_001363137.1 NP_001350066.1 protein LYRIC isoform 3
NM_001363138.1 NP_001350067.1 protein LYRIC isoform 4
NM_001363139.1 NP_001350068.1 protein LYRIC isoform 5
NM_178812.4 NP_848927.2 protein LYRIC isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NF-kappaB binding IPI
IPI: Inferred from physical interaction
16452207 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
18316612 GOA
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
21266579 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18316612 GOA
enables transcription coactivator activity IMP
IMP: Inferred from mutant phenotype
18316612 GOA
Biological Process GO Annotation Evidence References Source
involved in lipopolysaccharide-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
19740331 GOA
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
17704808 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15927426 GOA
involved in positive regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
16452207 GOA
involved in positive regulation of angiogenesis IDA
IDA: Inferred from direct assay
19940250 GOA
involved in positive regulation of autophagy IDA
IDA: Inferred from direct assay
21127263 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
16452207 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
17704808 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19648967 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
14980505 GOA
located in nuclear body IDA
IDA: Inferred from direct assay
19648967 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16452207 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
14980505 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein LYRIC

  • 3D3/LYRIC

MTDH Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MTDH Q86UE4 SND1 Homo sapiens Q7KZF4
Anti Tag CoIP
33961781
Intra
MTDH Q86UE4 SND1 Homo sapiens Q7KZF4
Anti Tag CoIP
28514442
Intra
MTDH Q86UE4 SND1 Homo sapiens Q7KZF4
Anti Tag CoIP
24981741
Intra
MTDH Q86UE4 SND1 Homo sapiens Q7KZF4
Anti Tag CoIP
34591612
Intra
MTDH Q86UE4 AGO2 Homo sapiens Q9UKV8
Anti Tag CoIP
24981741
Cross: Cross-species interaction Intra: Intraspecies interaction

MTDH Antibodies

Cat. No. Product Name Application Reactivity
HY-P81286 LYRIC Antibody (YA995) WB, IHC-P, FC Human
HY-P81286A LYRIC Antibody (YA996) WB, IHC-F, IHC-P, ICC/IF, IP Human
HY-P81286AA LYRIC Antibody (YA996)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human
HY-P84657 LYRIC/AEG1 Antibody (YA4354) WB, IHC-P, FC, ELISA Human
HY-P84657A LYRIC/AEG1 Antibody (YA4354)(PBS only) WB, IHC-P, FC, ELISA Human
HY-P84658 LYRIC/AEG1 Antibody (YA4355) WB, IHC-P, ICC/IF, FC, ELISA Human, Monkey
HY-P84658A LYRIC/AEG1 Antibody (YA4355)(PBS only) WB, IHC-P, ICC/IF, FC, ELISA Human, Monkey
HY-P85286 LYRIC/AEG1 Antibody (YA4978) WB; IHC-P; IHC-F; IF-Tissue Human, Mouse, Rat

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Glioblastoma

  • Glioblastoma Multiforme

  • Gbm

  • Adult Glioblastoma Multiforme

  • Grade Iv Adult Astrocytic Tumor

  • Primary Glioblastoma Multiforme

  • Spongioblastoma Multiforme

  • Adult Glioblastoma

  • Primary Glioblastoma
High Grade Glioma

  • Malignant Glioma

  • Glial Cell Tumor

  • Glioma, Malignant

  • Malignant Neuroglial Tumor

  • Neuroglial Tumor

  • Glioma

  • Malignant Gliomas
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Migraine, Familial Hemiplegic, 2

  • FHM2

  • Mhp2

  • Migraine, Familial Basilar

  • Familial Hemiplegic Migraine 2

  • Familial Hemiplegic Migraine-2

  • Familiar Basilar Migraine

  • Migraine, Hemiplegic, Familial, Type 2
Cataract 30

  • Cataract 30 Pulverulent

  • Cataract Coppock-Like

  • Ctrct30

  • Dusty Cataract

  • Cataract, Type 30
Migraine, Familial Hemiplegic, 3

  • FHM3

  • Familial Hemiplegic Migraine 3

  • Mhp3

  • Migraine, Hemiplegic, Familial, Type 3
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Huntington Disease

  • Huntington'S Disease

  • Huntington Chorea

  • Huntington'S Chorea

  • HD

  • Huntington Chronic Progressive Hereditary Chorea

  • Juvenile Huntington Disease

  • Chronic Progressive Chorea

  • Chronic Progressive Hereditary Chorea

  • Hc - [Huntington Chorea]

  • Hereditary Chorea

  • Progressive Hereditary Chorea
Migraine With Or Without Aura 1

  • Migraine

  • Migraine With Or Without Aura, Susceptibility To, 1

  • Migraine Disorder

  • Migraine Variant

  • Migraines

  • Migraine Disorders

  • Mgr1

  • Mgau

  • Ma

  • Migraine With Or Without Aura

  • Classic Migraine

  • Common Migraine

  • Disorder, Migraine

  • Headache Migraine

  • Headache Migrainous

  • Migraine Headache

  • Migraine Syndrome

  • Headache Including Migraine

  • Migraine, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-155170 MTDH-SND1 blocker 1 Inhibitor 99.33% Unkown
HY-160801 HKYK-0030 Inhibitor 99.38% Unkown
HY-168850 MTDH-SND1 blocker 2 Inducer 99.51% Unkown
HY-RS08762 MTDH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18775 Mtdh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25263 Mtdh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MTDH MGD MGI:1914404
Canis familiaris MTDH VGNC VGNC:43462
Macaca mulatta MTDH VGNC VGNC:74859
Felis catus MTDH VGNC VGNC:63643
Bos taurus MTDH VGNC VGNC:31719
Rattus norvegicus MTDH RGD RGD:620992
Others MTDH NCBI