LYRIC/AEG1 Antibody (YA4355)

Cat. No.: HY-P84658: Data Sheet User Guide for Antibodies
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LYRIC/AEG1 Antibody (YA4355) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LYRIC/AEG1.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

LYRIC/AEG1 Antibody (YA4355) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LYRIC/AEG1.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 64 kDa;

Observed band size: 72 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Monkey

SwissProt ID

Q86UE4

Gene ID

92140 [NCBI]

Immunogen

Purified recombinant fragment of human MTDH (AA: 200-450) expressed in mammalian.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-1:200
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS with 0.05% sodium azide

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance

Subcellular Localization：Endoplasmic reticulum membrane; Single-pass membrane protein; Nucleus membrane; Single-pass membrane protein; Cell junction, tight junction; Nucleus, nucleolus; Cytoplasm, perinuclear region

Expression：
Tissue_specificity:This gene is widely expressed in muscle-based organs (such as skeletal muscle, heart, tongue, and small intestine) and endocrine glands (such as the thyroid and adrenal glands) , with the highest expression levels. It is overexpressed in a variety of cancers, including breast cancer, brain cancer, prostate cancer, melanoma, and glioblastoma multiforme.

Induction:By TNF (at protein level) . By HIV-1 infection of primary fetal astrocytes

Subunit：Interacts with BCCIP, CREBBP/CBP and RELA/p65

Synonyms

3D3; AEG1; AEG-1; LYRIC; LYRIC/3D3

Documentation

User Guide for Antibodies (1077 KB)