NAC-1 Antibody (YA4983)
(Synonyms: NACC1; BTBD14B; NAC1; Nucleus accumbens-associated protein 1; NAC-1; BTB/POZ domain-containing protein 14B)NAC-1 Antibody (YA4983) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NAC-1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide.
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Conjugation:
Non-conjugated
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:10000 |
Product Details
NAC-1 Antibody (YA4983) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NAC-1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 58kDa;
Purified recombinant fragment of human NACC1 expressed in E. Coli. The exact sequence is proprietary to MCE.
Endogenous
affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines
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Subcellular Localization
Nucleus; Cytoplasm
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Expression
Tissue_specificity:Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer -
Subunit
Homooligomer; mediated by the BTB domain. Interacts with HDAC3 and HDAC4. Interacts (via BTB domain) with CUL3, PSMD7 and RCOR1
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SwissProt ID
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Synonyms
NACC1; BTBD14B; NAC1; Nucleus accumbens-associated protein 1; NAC-1; BTB/POZ domain-containing protein 14B
Documentation
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