NAIP Antibody
(Synonyms: Baculoviral IAP repeat-containing protein 1, Neuronal apoptosis inhibitory protein, NAIP, BIRC1)NAIP Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to NAIP.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:500-5000 | 1:200-500 | 1:50-200 |
Product Details
NAIP Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to NAIP.
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Host Rabbit
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Clonality polyclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 159.5 kDa;
Recombinant protein of Human NAIP.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NAIP is an Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy
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Expression
Tissue_Specificity: Expressed in motor neurons, but not in sensory neurons. Found in liver and placenta, and to a lesser extent in spinal cord. -
Isoforms & Post-Translational Modification
NAIP has 2 isoforms, Q13075-1: amino acid length is 1403, molecular weight is 159582 Da (predicted); Q13075-2: amino acid length is 1241, molecular weight is 141329 Da (predicted).
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Subunit
Interacts (via NACHT domain) with APAF1 (via CARD and NACHT domains).
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SwissProt ID
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Synonyms
Baculoviral IAP repeat-containing protein 1, Neuronal apoptosis inhibitory protein, NAIP, BIRC1
Documentation
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