NDN Antibody (YA7767)
(Synonyms: HsT16328; PWCR)NDN Antibody (YA7767) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NDN.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P, ICC/IF
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 |
Product Details
NDN Antibody (YA7767) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NDN.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 35.9 kDa
Full length human recombinant protein of human NDN produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NDN is a Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Also functions as a transcription factor and directly binds to specific guanosine-rich DNA sequences
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Subcellular Localization
Perikaryon,Nucleus
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Expression
Tissue_Specificity: Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Not detected in peripheral blood leukocytes. In brain, restricted to post-mitotic neurons -
Isoforms & Post-Translational Modification
Q99608: 321 amino acids, molecular weight 36086 Da.
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Subunit
Binds to the transactivation domains of E2F1 and p53
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SwissProt ID
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Synonyms
HsT16328; PWCR
Documentation
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