NDOR1 Antibody (YA8598)
(Synonyms: bA350O14.9; NR1)NDOR1 Antibody (YA8598) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NDOR1.
-
Host:
Mouse
-
Isotype:
IgG2a
-
Application:
IHC-P, ICC/IF
-
Reactivity :
Human, Dog, Mouse
-
Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 |
Product Details
NDOR1 Antibody (YA8598) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NDOR1.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman, Dog, Mouse
-
Calculated Molecular Weight Predicted band size: 66.6 kDa
Full length human recombinant protein of human NDOR1 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
-
Appearance
Liquid
-
Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
NDOR1 is a NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair. In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A[1][2][3][4][5][6].
-
Subcellular Localization
Cytoplasm, perinuclear region
-
Expression
Tissue_Specificity: Low expression in brain, heart, kidney, pancreas, prostate and skeletal muscle. Highest levels in the placenta. Expressed in cancer cell lines including promyelocytic leukemia, HeLaS3, chronic myelagenous leukemia, lymphoblastic leukemia, Burkitt's lymphoma, colorectal adenocarcinoma, lung carcinoma, and melanoma G-361 -
Isoforms & Post-Translational Modification
Q9UHB4 has four isomers: Q9UHB4-1: 66763 Da (predicted); Q9UHB4-2: 67688 Da (predicted); Q9UHB4-3: 58455 Da (predicted); Q9UHB4-4: 65943 Da (predicted).
-
Subunit
Interacts with CIAPIN1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery (By similarity) (PubMed:20802492, PubMed:23596212)
-
SwissProt ID
-
Synonyms
bA350O14.9; NR1
Documentation
Powered by Bioz
