Nectin 2 Antibody (YA7653)
(Synonyms: CD112, HVEB, PRR2, PVRL2, NECTIN2, Nectin-2, Herpes virus entry mediator B, Nectin cell adhesion molecule 2, Poliovirus receptor-related protein 2, Herpesvirus entry mediator B, HveB)
Based on 1 Customer Validation
Nectin 2 Antibody (YA7653) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nectin 2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF, IP, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IP
IP: Immunoprecipitation
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FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:50-200 | 1:20-50 | 1:50-100 |
Product Details
Nectin 2 Antibody (YA7653) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nectin 2.
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Host Rabbit
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Clonality Recombinant
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Species ReactivityHuman, Mouse, Rat Predicted Reactivity: Mouse,Rat
Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
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Observed Molecular WeightObserved band size: 65 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 58 kDa
A synthesized peptide derived from human Nectin 2: 490-538/538.
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Nectin 2 is a Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein |(Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV)[1][2].
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Subcellular Localization
Cell membrane
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Expression
Tissue_Specificity: Ubiquitous -
Isoforms & Post-Translational Modification
Q92692 has two isomers: Q92692-1: 57742 Da (predicted); Q92692-2: 51359 Da (predicted).
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Subunit
Can form trans-heterodimers with NECTIN3 (By similarity)
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SwissProt ID
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Synonyms
CD112, HVEB, PRR2, PVRL2, NECTIN2, Nectin-2, Herpes virus entry mediator B, Nectin cell adhesion molecule 2, Poliovirus receptor-related protein 2, Herpesvirus entry mediator B, HveB
Documentation
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