Nesprin3 Antibody (YA9758)
(Synonyms: SYNE3, Spectrin Repeat Containing Nuclear Envelope Family Member 3, Nesprin-3, LINC00341, NET53, Long Intergenic Non-Protein Coding RNA 341, Nuclear Envelope Spectrin Repeat Protein 3, KASH Domain-Containing Protein 3, NCRNA00341, C14orf139, FLJ25605, C14orf49, Nesp3, KASH3, Chromosome 14 Open Reading Frame 139, Chromosome 14 Open Reading Frame 49, Uncharacterized Protein C14orf113, Non-Protein Coding RNA 341, C14ORF139, NESPRIN-3, C14ORF49, NESP3)Nesprin3 Antibody (YA9758) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to Nesprin3.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, FC, ICC/IF
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH 7.4) containing 50% glycerol, 0.05% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-5000 | 1:200-2000 | 1:100-1000 |
Product Details
Nesprin3 Antibody (YA9758) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to Nesprin3.
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Host Rabbit
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 100 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 112 kDa,
A synthesized peptide derived from human Nesprin3
affinity purified.
Non-conjugated
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4) containing 50% glycerol, 0.05% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Nesprin3 is an As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells
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Subcellular Localization
Nucleus outer membrane; Nucleus envelope; Rough endoplasmic reticulum
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Expression
Tissue_Specificity: Expressed in aortic endothelial cells (at protein level). -
Isoforms & Post-Translational Modification
Nesprin3 has 3 isoforms, Q6ZMZ3-1: amino acid length is 975, molecular weight is 112216 Da (predicted); Q6ZMZ3-2: amino acid length is 970, molecular weight is 111677 Da (predicted); Q6ZMZ3-3: amino acid length is 596, molecular weight is 68582 Da (predicted).
The disulfid bond with SUN1 or SUN2 is required for stability of the respective LINC complex under tensile forces. -
Subunit
Core component of LINC complexes which are composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins.
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SwissProt ID
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Synonyms
SYNE3, Spectrin Repeat Containing Nuclear Envelope Family Member 3, Nesprin-3, LINC00341, NET53, Long Intergenic Non-Protein Coding RNA 341, Nuclear Envelope Spectrin Repeat Protein 3, KASH Domain-Containing Protein 3, NCRNA00341, C14orf139, FLJ25605, C14orf49, Nesp3, KASH3, Chromosome 14 Open Reading Frame 139, Chromosome 14 Open Reading Frame 49, Uncharacterized Protein C14orf113, Non-Protein Coding RNA 341, C14ORF139, NESPRIN-3, C14ORF49, NESP3
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