NEU2 Antibody (YA8518)
(Synonyms: SIAL2)NEU2 Antibody (YA8518) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NEU2.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
ICC/IF, FC
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:100-250 | 1:100 |
Product Details
NEU2 Antibody (YA8518) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NEU2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 42.1 kDa
Full length human recombinant protein of human NEU2 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NEU2 is an Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form. Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues[1][2].
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Subcellular Localization
Cytoplasm, cytosol
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Expression
Tissue_Specificity: Expressed in skeletal muscle, fetal liver and embryonic carcinoma cell line NT2-D1 -
Isoforms & Post-Translational Modification
Q9Y3R4: 380 amino acids, molecular weight 42254 Da.
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SwissProt ID
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Synonyms
SIAL2
Documentation
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