NF1 Antibody
(Synonyms: Neurofibromin, Neurofibromatosis-related protein NF-1, NF1)NF1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to NF1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:100-500 |
Product Details
NF1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to NF1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 250 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 319 kDa
Synthetic peptide corresponding to the center region of human NF1.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NF1 stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity
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Subcellular Localization
Nucleus; Nucleus, nucleolus; Cell membrane
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Expression
Tissue_Specificity: Detected in brain, peripheral nerve, lung, colon and muscle. -
Isoforms & Post-Translational Modification
NF1 has 6 isoforms, P21359-1: amino acid length is 2839, molecular weight is 319372 Da (predicted); P21359-2: amino acid length is 2818, molecular weight is 317033 Da (predicted); P21359-3: amino acid length is 551, molecular weight is 62300 Da (predicted); P21359-4: amino acid length is 1598, molecular weight is 180213 Da (predicted); P21359-5: amino acid length is 593, molecular weight is 67543 Da (predicted); P21359-6: amino acid length is 2836, molecular weight is 318992 Da (predicted).可被 RNF7/RBX2 泛素化，进而导致其降解NF1 存在 6 个异构体，P21359-1：氨基酸个数为 2839 个，分子量为 319372 Da (预测)；P21359-2：氨基酸个数为 2818 个，分子量为 317033 Da (预测)；P21359-3：氨基酸个数为 551 个，分子量为 62300 Da (预测)；P21359-4：氨基酸个数为 1598 个，分子量为 180213 Da (预测)；P21359-5：氨基酸个数为 593 个，分子量为 67543 Da (预测)；P21359-6：氨基酸个数为 2836 个，分子量为 318992 Da (预测)。Ubiquitinated by RNF7/RBX2, leading to its degradation
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Subunit
Interacts with HTR6.
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SwissProt ID
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Synonyms
Neurofibromin, Neurofibromatosis-related protein NF-1, NF1
Documentation
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