NOTCH4 Antibody (YA4442)

Cell membrane; Single-pass type I membrane protein; Nucleus

Tissue_specificity:This gene is highly expressed in the heart, moderately expressed in the lungs and placenta, and lowly expressed in the liver, skeletal muscle, kidneys, pancreas, spleen, lymph nodes, thymus, bone marrow, and fetal liver. It is not expressed in adult brain tissue or peripheral blood leukocytes.

Q99466 has 3 isomers: Q99466-1: 209622 Da (predicted); Q99466-2: 61262 Da (predicted); Q99466-3: 39617 Da (predicted).
Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity);Phosphorylated

Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity). Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH4

Q99466

INT3