NrCAM Antibody (YA4402)
(Synonyms: NRCAM)NrCAM Antibody (YA4402) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NrCAM.
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Host:
Mouse
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Isotype:
IgG1
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Application:
ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|
| Dilution Ratio | 1:50 ELISA: 1:10000 |
Product Details
NrCAM Antibody (YA4402) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NrCAM.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 144 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 144 kDa
Purified recombinant fragment of human NRCAM (AA: 1192-1255) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NrCAM cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Cell projection, axon; Secreted
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Expression
Tissue_specificity:The substance was detected in all examined tissues. In the brain, it was detected in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus, and thalamus. -
Isoforms & Post-Translational Modification
Q92823 has 6 isomers: Q92823-1: 143890 Da (predicted); Q92823-2: 136614 Da (predicted); Q92823-3: 130668 Da (predicted); Q92823-4: 131046 Da (predicted); Q92823-5: 144375 Da (predicted); Q92823-6: 131744 Da (predicted).
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Subunit
Constituent of a NFASC/NRCAM/ankyrin-G complex. Detected in a complex with CNTN1 and PTPRB. Interacts with GLDN/gliomedin (By similarity). Interacts with MYOC (PubMed:23897819)
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SwissProt ID
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Synonyms
NRCAM
Documentation
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