p38β Antibody (YA5003)

p38β (MAPK11) is a stress-activated serine/threonine MAPK within the p38α, p38β, p38γ, and p38δ family, which transduces extracellular stress signals into cellular adaptation and survival responses^[1]. Mechanistically, p38β belongs to the broader p38 MAPK pathway involved in inflammation, stress response, transcription, growth, differentiation, motility, and survival^[1]. In endothelial cells, SOCE activates CaMKKβ-AMPKα1-p38β MAPK signaling, and p38β phosphorylates STIM1 to suppress store-operated Ca²⁺ entry and permeability responses^[2]. In disease models, SARS-CoV-2 requires p38β as a critical host factor for viral replication after viral mRNA expression, supporting p38β-focused antiviral research^[3]. Compared with p38α, p38β shows distinct functional relevance because SARS-CoV-2 proviral activity was reported for p38β but not shared with p38α^[3]. The isoform distinction also matters for inhibitor design because p38α/MAPK14 is described as the major proinflammatory member, whereas p38β/MAPK11 is treated as a noninflammatory isoform in substrate-selective inhibitor development^[4]. For experimental applications, p38 catalytic inhibitors such as SB203580 lack isoform specificity, limiting interpretation of p38β biology in complex disease models^[1][4]. Therefore, p38β research benefits from isoform-aware genetic depletion, phosphoproteomics, and selective inhibitor strategies that separate p38β-dependent biology from p38α-driven inflammatory signaling^[3][4].