p73 Antibody (YA7659)

Cat. No.: HY-P87974: Data Sheet User Guide for Antibodies
FAQs
Technical Support

p73 Antibody (YA7659) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p73.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

사이즈		재고
50 μL		견적 받기
100 μL		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명

제품 설명

p73 Antibody (YA7659) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p73.

Host

Rabbit

Clonality

Recombinant

분자량

Predicted band size: 70 kDa;

Observed band size: 70 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human Predicted Reactivity: Mouse,Rat

Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.

SwissProt ID

O15350

Immunogen

A synthesized peptide derived from human p73

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-200
IHC-F IHC-F: Immunohistochemistry-Frozen	1:100-200
IF-Tissue IF-Tissue: Immunofluorescence-Tissue	1:50-200
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-200

Sensitivity	Endogenous	Purity	affinity purified by Protein A
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761)

Subcellular Localization：Nucleus,Cytoplasm

Expression：
Tissue_Specificity: Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue. Expressed in the respiratory epithelium (PubMed:34077761)
Induction: Not induced by DNA damage. Isoforms lacking the transactivation domain block gene induction

Isoforms & Post-Translational Modification：O15350 has 12 isomers: O15350-1: 69623 Da (predicted); O15350-2: 54322 Da (predicted); O15350-3: 53026 Da (predicted); O15350-4: 44517 Da (predicted); O15350-5: 61694 Da (predicted); O15350-6: 59887 Da (predicted); O15350-8: 64422 Da (predicted); O15350-9: 49121 Da (predicted); O15350-10: 47824 Da (predicted); O15350-11: 62034 Da (predicted); O15350-12: 38874 Da (predicted). O15350-13: 61694 DA (prediction).
Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not affect transcriptional activity丨Higher levels of phosphorylation seen in the brain from patients with Huntington disease丨Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome

Subunit：Found in a complex with p53/TP53 and CABLES1

각종 서류

User Guide for Antibodies (1077 KB)