p73 Antibody (YA7659)
(Synonyms: P73, TP73, Tumor protein p73, p53-like transcription factor, p53-related protein)
Based on 1 Customer Validation
p73 Antibody (YA7659) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p73.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
IHC-P, IHC-F, ICC/IF, IF-Tissue
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
IHC-F
IHC-F: Immunohistochemistry-Frozen
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
|
|---|---|---|---|---|
| Dilution Ratio | 1:50-200 | 1:50-200 | 1:50-200 | 1:50-200 |
Product Details
p73 Antibody (YA7659) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p73.
-
Host Rabbit
-
Clonality Recombinant
-
Species ReactivityHuman, Mouse, Rat Predicted Reactivity: Mouse,Rat
Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
-
Observed Molecular WeightObserved band size: 70 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 70 kDa
A synthesized peptide derived from human p73: 55-80.
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
-
Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
p73 participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression. It is an essential factor for the positive regulation of lung ciliated cell differentiation[1].
-
Subcellular Localization
Nucleus,Cytoplasm
-
Expression
Tissue_Specificity: Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue. Expressed in the respiratory epithelium (PubMed:34077761)
Induction: Not induced by DNA damage. Isoforms lacking the transactivation domain block gene induction -
Isoforms & Post-Translational Modification
O15350 has 12 isomers: O15350-1: 69623 Da (predicted); O15350-2: 54322 Da (predicted); O15350-3: 53026 Da (predicted); O15350-4: 44517 Da (predicted); O15350-5: 61694 Da (predicted); O15350-6: 59887 Da (predicted); O15350-8: 64422 Da (predicted); O15350-9: 49121 Da (predicted); O15350-10: 47824 Da (predicted); O15350-11: 62034 Da (predicted); O15350-12: 38874 Da (predicted). O15350-13: 61694 DA (prediction).
Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not affect transcriptional activity丨Higher levels of phosphorylation seen in the brain from patients with Huntington disease丨Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome -
Subunit
Found in a complex with p53/TP53 and CABLES1
-
SwissProt ID
-
Synonyms
P73, TP73, Tumor protein p73, p53-like transcription factor, p53-related protein
Documentation
Powered by Bioz
