PAPPA Antibody (YA7154)
(Synonyms: Pappalysin-1, Insulin-like growth factor-dependent IGF-binding protein 4 protease, Pregnancy-associated plasma protein A, IGF-dependent IGFBP-4 protease, IGFBP-4ase, PAPP-A, PAPPA)PAPPA Antibody (YA7154) is a Mouse-derived and non-conjugated IgG1, Kappa monoclonal antibody, targeting to PAPPA.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P, IHC-F, ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:100-200 | 1:100-200 | 1:100-200 | 1:30-3000 |
Product Details
PAPPA Antibody (YA7154) is a Mouse-derived and non-conjugated IgG1, Kappa monoclonal antibody, targeting to PAPPA.
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Host Mouse
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 170kDa;
KLH conjugated synthetic peptide derived from human PAPPA
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PAPPA is a Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF
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Subcellular Localization
Secreted
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Expression
Tissue_Specificity: High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts
Induction: By 8-bromoadenosine-3',5'-phosphate -
Isoforms & Post-Translational Modification
Q13219: 1627 amino acids, molecular weight 180973 Da.
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Subunit
Homodimer; disulfide-linked
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SwissProt ID
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Synonyms
Pappalysin-1, Insulin-like growth factor-dependent IGF-binding protein 4 protease, Pregnancy-associated plasma protein A, IGF-dependent IGFBP-4 protease, IGFBP-4ase, PAPP-A, PAPPA
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