PAX5 Antibody (YA5579)
(Synonyms: Paired box protein Pax-5; B-cell-specific transcription factor; BSAP; )PAX5 Antibody (YA5579) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to PAX5.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P, WB, ICC/IF, ELISA
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:200-1000 | 1:500-2000 | 1:100-500 | 1:1000-5000 |
Product Details
PAX5 Antibody (YA5579) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to PAX5.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 42 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 42 kDa
Synthesized peptide derived from human PAX-5 AA range: 300-383
Protein G
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PAX5 transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage. Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes. In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage. Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire; (Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription. Also participates in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity[1][2][3][4][5].
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Subcellular Localization
Nucleus
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Isoforms & Post-Translational Modification
Q02548 has 11 isomers: Q02548-1: 42149 Da (predicted); Q02548-2: 38890 Da (predicted); Q02548-3: 35281 Da (predicted); Q02548-4: 32471 Da (predicted); Q02548-5: 31830 Da (predicted); Q02548-6: 38773 Da (predicted); Q02548-7: 35514 Da (predicted); Q02548-8: 37834 Da (predicted); Q02548-9: 34574 Da (predicted); Q02548-10: 31381 Da (predicted); Q02548-11: 34132 Da (predicted).
O-glycosylated;Phosphorylated by SYK. This phosphorylation plays an important role in the abolition of BLIMP1 repression by PAX5 in order to trigger plasma cell differentiation -
Subunit
Interacts with ETS1; this interaction alters PAX5 DNA-binding properties (PubMed:11779502). Binds DNA as a monomer (PubMed:11779502). Interacts with TBP; this interaction allows PAX5 to interact with the basal transcription machinery (PubMed:10197586). Interacts with RB1 (PubMed:10197586). Interacts with TLE4 (PubMed:10811620). Interacts with DAXX (By similarity)
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SwissProt ID
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Synonyms
Paired box protein Pax-5; B-cell-specific transcription factor; BSAP;
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