PCGF6 Antibody (YA1545)
(Synonyms: RING finger protein 134; Mel18 and Bmi1-like RING finger)PCGF6 Antibody (YA1545) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PCGF6.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF, IP
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Reactivity :
Mouse, Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IP
IP: Immunoprecipitation
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|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:200 | 1:20 |
Product Details
PCGF6 Antibody (YA1545) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PCGF6.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityMouse, Rat
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Observed Molecular WeightObserved band size: 40 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 40 kDa
Entrez Gene: 71041 Mouse ; 309457 Rat
SwissProt: Q99NA9 Mouse ; Q5XI70 Rat ;
Recombinant protein of mouse PCGF6
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PCGF6 transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity
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Subcellular Localization
Nucleus
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Expression
Tissue_specificity:Expressed in ovary, testis, stomach, liver, thymus and kidney (at protein level) -
Subunit
Component of a PRC1-like complex. Interacts with BMI1/PCGF4, RING1 and RNF2. Interacts with KDM5D. Interacts with CBX4, CBX6, CBX7 and CBX8
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SwissProt ID
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Synonyms
RING finger protein 134; Mel18 and Bmi1-like RING finger
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Research Field
Epigenetics and Nuclear Signaling
Documentation
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