PLZF Antibody (YA4186)(PBS only)
(Synonyms: PLZF; ZNF145; ZBTB16)PLZF Antibody (YA4186) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PLZF.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:10000 |
Product Details
PLZF Antibody (YA4186) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PLZF.
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Host Mouse
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 74 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 74 kDa
Purified recombinant fragment of human ZBTB16 aa 1-254.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PLZF acts as a transcriptional repressor. Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins[1][2][3].
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Subcellular Localization
Nucleus; Nucleus, nuclear body
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Expression
Tissue_specificity:In the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines, and peripheral blood mononuclear cells. It is also expressed in the ovary, with lower levels in the kidney and lung.
Induction:By retinoic acid -
Isoforms & Post-Translational Modification
Q05516 has 2 isomers: Q05516-1: 74274 Da (predicted); Q05516-2: 61601 Da (predicted).
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Subunit
Binds EPN1 (PubMed:11161217). Interacts with ZBTB32 and CUL3 (PubMed:10572087, PubMed:14528312). Interacts with ATP7B (PubMed:16676348). Interacts with transcriptional corepressor RUNX1T1 (via its N-terminus); the interaction increases the transcription repression activity of ZBTB16 (PubMed:10688654). Interacts (via C2H2-type zinc finger domains 1 and 2) with RNF112 (PubMed:24359566)
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SwissProt ID
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Synonyms
PLZF; ZNF145; ZBTB16
Documentation
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