PSMA Antibody (YA1764)

Cat. No.: HY-P82019: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

PSMA Antibody (YA1764) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PSMA.

For research use only. We do not sell to patients.

Size	Stock	Quantity
Free Sample	Apply now
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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PSMA Antibody (YA1764) Featured Recommendations:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
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Background
Documentation

Description

PSMA Antibody (YA1764) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PSMA.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 84 kDa;

Observed band size: 100 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q04609

Gene ID

2346 [NCBI]

Immunogen

A synthetic peptide of human PSMA aa361-374.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000

Sensitivity	Endogenous	Purity	Affinity Purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Verification Image

Western blot analysis of extracts from NIH/3T3(lane 2(20ug) and NIH/3T3(lane 3(40ug) using PSMA Antibody (HY-P82019) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P83730, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

Background

Function：Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression; Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC

Subcellular Localization：Cell membrane; Single-pass type II membrane protein; Cytoplasm

Expression：
Tissue_specificity:It is highly expressed in prostate epithelial cells. It can be detected in the bladder, kidneys, testes, ovaries, fallopian tubes, breasts, adrenal glands, liver, esophagus, stomach, small intestine, colon, and brain (protein level) . It can also be detected in the capillary endothelial cells of the small intestine, brain, kidneys, liver, spleen, colon, trachea, spinal cord, and various tumors. It is specifically expressed in the brush border membrane of the jejunum. In the brain, it is highly expressed in the ventral striatum and brainstem. It is also expressed in fetal liver and kidneys. The PSMA' subtype is the most abundant subtype in normal prostate. The PSMA-1 subtype is the most abundant subtype in primary prostate tumors. The PSMA-9 subtype is specifically expressed in prostate cancer.

Induction:In the prostate, up-regulated in response to androgen deprivation

Isoforms & Post-Translational Modification：Q04609 has 8 isomers: Q04609-1: 84331 Da (predicted); Q04609-3: 78065 Da (predicted); Q04609-4: 27811 Da (predicted); Q04609-6: 78000 Da (predicted); Q04609-7: 82519 Da (predicted); Q04609-8: 80597 Da (predicted); Q04609-9: 78785 Da (predicted); Q04609-10: 50090 Da (predicted).
The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis;The N-terminus is blocked

Subunit：Homodimer

RRID

AB_3104140

Database

Entrez Gene: 2346 Human

SwissProt: Q04609 Human

OMIM: 600934 Human

Research Field

Signal Transduction

Synonyms

FGCP; FOLH 1; GCP 2; GCPII; mGCP; NAALADase I; PSM; PSMA

Documentation

Select Batch:

Data Sheet (234 KB) SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

PSMA Antibody (YA1764) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PSMA Antibody (YA1764)

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