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RAB17 Antibody (YA8376)(PBS only)

(Synonyms: FLJ12538)

RAB17 Antibody (YA8376) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RAB17.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P, ICC/IF

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • RAB17 Antibody (YA8376)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
Dilution Ratio 1:50-250 1:100-250

Product Details

Description

RAB17 Antibody (YA8376) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RAB17.

  • Host Mouse
  • Species Reactivity
    Human
  • Calculated Molecular Weight Predicted band size: 23.3 kDa
Immunogen

Full length human recombinant protein of human RAB17 produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    RAB17 is a The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB17 is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development. May also play a role in cell migration[1].

  • Subcellular Localization

    Recycling endosome membrane,Melanosome,Cell projection, dendrite

  • Expression


    Tissue_Specificity: Expressed in melanocytes (at protein level)
    Induction: Up-regulated by forskolin probably through the transcription factor MITF

  • Isoforms & Post-Translational Modification

    Q9H0T7 has two isomers: Q9H0T7-1: 23491 Da (predicted); Q9H0T7-2: 9394 Da (predicted).

  • SwissProt ID

    Q9H0T7

  • Synonyms

    FLJ12538

RAB17 Antibody (YA8376)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • RAB17 Antibody (YA8376)(PBS only) Product Image