RAB17 Antibody (YA8376)(PBS only)

Cat. No.: HY-P88692A: Data Sheet User Guide for Antibodies
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RAB17 Antibody (YA8376) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RAB17.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

RAB17 Antibody (YA8376) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RAB17.

Host

Mouse

Molecular Weight

Predicted band size: 23.3 kDa

Species Reactivity

Human

SwissProt ID

Q9H0T7

Immunogen

Full length human recombinant protein of human RAB17 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-250
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB17 is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration (PubMed:22328529)

Subcellular Localization：Recycling endosome membrane,Melanosome,Cell projection, dendrite

Expression：
Tissue_Specificity: Expressed in melanocytes (at protein level)
Induction: Up-regulated by forskolin probably through the transcription factor MITF

Isoforms & Post-Translational Modification：Q9H0T7 has two isomers: Q9H0T7-1: 23491 Da (predicted); Q9H0T7-2: 9394 Da (predicted).

Synonyms

FLJ12538

Documentation

User Guide for Antibodies (1077 KB)