RAB24 Antibody (YA8148)
(Synonyms: member RAS oncogene family; RAB24; RAB24 gene product)RAB24 Antibody (YA8148) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RAB24.
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Host:
Mouse
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Isotype:
IgG1
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Application:
ICC/IF
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Reactivity :
Human, Dog, Mouse
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|
| Dilution Ratio | 1:100-250 |
Product Details
RAB24 Antibody (YA8148) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RAB24.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Dog, Mouse
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Calculated Molecular Weight Predicted band size: 22.9 kDa
Full length human recombinant protein of human RAB24 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RAB24 is a The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB24 is an atypical RAB protein that presents low GTPase activity and thereby exists predominantly in the GTP-bound active state. RAB24 is required for the clearance of late autophagic vacuoles under basal conditions. It is not needed for starvation-induced autophagy. Involved in the modulation of meiotic apparatus assembly and meiotic progression during oocyte maturation, possibly through regulation of kinetochore-microtubule interaction
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Subcellular Localization
Cytoplasm, cytosol,Membrane,Cytoplasmic vesicle, autophagosome membrane,Cytoplasm, perinuclear region,Cytoplasm, cytoskeleton, spindle
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Expression
Induction: By extensive retinoic acid treatment, in Ntera-2 teratoma cell line induced to differentiate into postmitotic neurons (NTN2) (at protein level)
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Isoforms & Post-Translational Modification
Q969Q5: 203 amino acids, molecular weight 23124 Da.
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Subunit
Interacts with ZFYVE20 (PubMed:16034420)
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SwissProt ID
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Synonyms
member RAS oncogene family; RAB24; RAB24 gene product
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