RPL23A Antibody
(Synonyms: Large ribosomal subunit protein uL23, 60S ribosomal protein L23a, RPL23A)RPL23A Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to RPL23A.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:50-200 |
Product Details
RPL23A Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to RPL23A.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 19 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 17 kDa
Purified recombinant protein of human RPL23A
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RPL23A is a Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination[1][2][3].
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Subcellular Localization
Cytoplasm; Nucleus
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Expression
Induction: May be down-regulated by GNL2 (at protein level). -
Isoforms & Post-Translational Modification
RPL23A has an amino acid length of 156, molecular weight is 17695 Da.
N-terminus is methylated by METTL11A/NTM1. -
Subunit
Component of the large ribosomal subunit.
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SwissProt ID
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Synonyms
Large ribosomal subunit protein uL23, 60S ribosomal protein L23a, RPL23A
Documentation
[1]. Anger AM, et al. Structures of the human and Drosophila 80S ribosome. Nature. 2013 May 2;497(7447):80-5. [Content Brief]
[2]. Liang X, et al. Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat Commun. 2020 Jul 15;11(1):3542. [Content Brief]
[3]. Datta D, et al. Nucleolar GTP-binding Protein-1 (NGP-1) Promotes G1 to S Phase Transition by Activating Cyclin-dependent Kinase Inhibitor p21 Cip1/Waf1. J Biol Chem. 2015 Aug 28;290(35):21536-52. [Content Brief]
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