SAGE1 Antibody (YA1150)
(Synonyms: SAGE; SAGE1; Sarcoma antigen 1; Cancer/testis antigen 14 (CT14))SAGE1 Antibody (YA1150) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SAGE1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.305.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:100-1:200 |
Product Details
SAGE1 Antibody (YA1150) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SAGE1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 120 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 99 kDa
Recombinant protein of human SAGE1
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.305.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Sarcoma antigen 1 (SAGE1) is a cancer/testis antigen, primarily highly expressed in testicular spermatogonia, and also expressed in a few tissues such as the pituitary gland and gonads. SAGE1 is abnormally activated and overexpressed in various malignant tumors, including sarcoma, lung cancer, bladder cancer, and head and neck cancer. Its abnormal activation is associated with tumor progression, invasiveness, and poor prognosis. SAGE1 promotes homologous recombination repair (HR) while inhibiting non-homologous end joining (NHE), shifting DNA double-strand break (DSB) repair toward the more precise HR pathway, thereby reducing mutations[1].
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Subcellular Localization
Nucleus
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Expression
Tissue_specificity:Expressed mainly in bladder, lung, head and neck carcinomas. Not expressed in normal tissues except for testis -
SwissProt ID
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Synonyms
SAGE; SAGE1; Sarcoma antigen 1; Cancer/testis antigen 14 (CT14)
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Research Field
Cancer
Documentation
References
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