Semaphorin 7A Antibody (YA3232)
(Synonyms: JMH; CD108; SEMAL; CDw108; SEMAK1; H-Sema-L; H-SEMA-K1)
Based on 1 Customer Validation
Semaphorin 7A Antibody (YA3232) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Semaphorin 7A.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, FC, IP
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Reactivity :
Human
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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IP
IP: Immunoprecipitation
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 | 1:200-1:500 | 1:20-1:50 |
Product Details
Semaphorin 7A Antibody (YA3232) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Semaphorin 7A.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 75 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 75 kDa
Recombinant protein of human Semaphorin 7a aa45-648.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Semaphorin 7A plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes
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Subcellular Localization
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side
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Expression
Tissue_specificity:Protein levels were detected in keratinocytes and vascular endothelial cells of the skin. It was also expressed in fibroblasts, keratinocytes, melanocytes, placenta, testes, ovaries, spleen, brain, spinal cord, lungs, heart, adrenal glands, lymph nodes, thymus, intestines, and kidneys.
Induction:Up-regulated in UV-irradiated fibroblasts, but not in UV-irradiated keratinocytes -
Isoforms & Post-Translational Modification
O75326 has 2 isomers: O75326-1: 74824 Da (predicted); O75326-2: 73364 Da (predicted).
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Subunit
Interacts with ITGA1 and ITGB1 (Probable). Interacts with PLXNC1
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SwissProt ID
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Synonyms
JMH; CD108; SEMAL; CDw108; SEMAK1; H-Sema-L; H-SEMA-K1
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Research Field
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Documentation
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Data Sheet (234 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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User Guide for Antibodies (1077 KB)
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