SH2D2A Antibody (YA8315)
(Synonyms: F2771; SCAP; TSAD; VRAP)SH2D2A Antibody (YA8315) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SH2D2A.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P, ICC/IF, FC
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 | 1:100 |
Product Details
SH2D2A Antibody (YA8315) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SH2D2A.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 42.8 kDa
Full length human recombinant protein of human SH2D2A produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SH2D2A is a Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation
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Subcellular Localization
Cytoplasm
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Expression
Tissue_Specificity: Expression limited to tissues of the immune system and, in particular, activated T-cells. Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain, placenta, skeletal muscle, prostate, testis, ovary, small intestine, and colon. Expressed at low levels in unstimulated T-cells, but not expressed in normal resting or activated B-cells. According to PubMed:10692392, expression is not restricted to activated T-cells, but strongly expressed in blood cell lineages, the endothelium and other cell and tissue types, such as heart, lung, and liver
Induction: Rapidly induced after activation of T-cells. However, the gene continues to be expressed in long-term cultures of activated T-cells -
Isoforms & Post-Translational Modification
Q9NP31 has four isomers: Q9NP31-1: 42934 Da (predicted); Q9NP31-2: 44078 Da (predicted); Q9NP31-3: 39846 Da (predicted); Q9NP31-4: 40954 Da (predicted).
Phosphorylated on tyrosine residues -
Subunit
Interacts with KDR
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SwissProt ID
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Synonyms
F2771; SCAP; TSAD; VRAP
Documentation
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