SLA2 Antibody (YA8194)
(Synonyms: C20orf156; MARS; SLAP-2; SLAP2)SLA2 Antibody (YA8194) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to SLA2.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
IHC-P, ICC/IF, FC
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 | 1:100 |
Product Details
SLA2 Antibody (YA8194) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to SLA2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 28.4 kDa
Full length human recombinant protein of human SLA2 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SLA2 is an Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins
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Subcellular Localization
Cytoplasm,Cell membrane,Cytoplasmic vesicle,Cytoplasm
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Expression
Tissue_Specificity: Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon -
Isoforms & Post-Translational Modification
Q9H6Q3 has four isomers: Q9H6Q3-1: 28585 Da (predicted); Q9H6Q3-2: 23103 Da (predicted); Q9H6Q3-3: 25862 Da (predicted); Q9H6Q3-4: 20380 Da (predicted).
Phosphorylated by CSF1R -
Subunit
Interacts (via SH2 domain) with ZAP70 (phosphorylated) and CD3Z (phosphorylated)
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SwissProt ID
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Synonyms
C20orf156; MARS; SLAP-2; SLAP2
Documentation
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