SLC2A14 Antibody (YA4379)
(Synonyms: GLUT14; SLC2A3P3)SLC2A14 Antibody (YA4379) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to SLC2A14.
-
Host:
Mouse
-
Isotype:
IgG2a
-
Application:
IHC-P, ICC/IF, ELISA
-
Reactivity :
Human
-
Formulation:
Supplied in PBS with 0.05% sodium azide
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
|
|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:1000 | 1:10000 |
Product Details
SLC2A14 Antibody (YA4379) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to SLC2A14.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman
-
Calculated Molecular Weight Predicted band size: 56.3 kDa
Purified recombinant fragment of human SLC2A14 (AA: extra mix) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG2a
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS with 0.05% sodium azide
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
SLC2A14 is an Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53. Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M[1][2][3][4][5][6][7][8][9].
-
Subcellular Localization
Nucleus
-
Expression
Tissue_specificity:It is highly expressed in the heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon, and leukocytes. -
Subunit
Interacts with AHR; interaction is direct (PubMed:12215427). Interacts with NUB1; interaction is direct (PubMed:11259415). Interacts with ESR1 (By similarity)
-
SwissProt ID
-
Synonyms
GLUT14; SLC2A3P3
Documentation
Powered by Bioz
