SMC5 Antibody (YA7005)
(Synonyms: hSMC 5 antibody; hSMC5 antibody; KIAA0594 antibody; MLZ-453 antibody; OTTHUMP00000063367 antibody; SMC 5 antibody; SMC 5 structural maintenance of chromosomes 5 like 1 antibody; SMC protein 5 antibody; SMC-5 antibody; smc5 antibody)
Based on 1 Customer Validation
SMC5 Antibody (YA7005) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SMC5.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, ICC/IF, IHC-P
-
Reactivity :
Human, Mouse, Rat, Monkey
-
Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
|---|---|---|---|
| Dilution Ratio | 1:5000 | 1:100 | 1:200 |
Product Details
SMC5 Antibody (YA7005) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SMC5.
-
Host Rabbit
-
Clonality Recombinant,Monoclonal
-
Species ReactivityHuman, Mouse, Rat, Monkey
-
Observed Molecular WeightObserved band size: 129 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 129 kDa
Recombinant protein within human SMC5 aa 901-1,101.
Endogenous
Protein A affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
-
Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
SMC5 core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome[1].
-
Subcellular Localization
Nucleus,Chromosome,Nucleus, PML body,Chromosome, telomere
-
Expression
Tissue_Specificity: Widely expressed (PubMed:11408570). Strongly expressed in testis (PubMed:11408570) -
Subunit
Forms a heterodimer with SMC6 (PubMed:11408570)
-
SwissProt ID
-
Synonyms
hSMC 5 antibody; hSMC5 antibody; KIAA0594 antibody; MLZ-453 antibody; OTTHUMP00000063367 antibody; SMC 5 antibody; SMC 5 structural maintenance of chromosomes 5 like 1 antibody; SMC protein 5 antibody; SMC-5 antibody; smc5 antibody
Documentation
-
Data Sheet (231 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
User Guide for Antibodies (1077 KB)
Powered by Bioz
