SMC5 Antibody (YA7005)

製品番号: HY-P87322: データシート SDS COA User Guide for Antibodies
FAQs
Technical Support

SMC5 Antibody (YA7005) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SMC5.

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容量	価格（税別）	在庫状況	数量
20 μL	$167	在庫あり	Estimated Time of Arrival: December 31
50 μL	$252	在庫あり	Estimated Time of Arrival: December 31
100 μL	$408	在庫あり	Estimated Time of Arrival: December 31
250 μL		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明

製品説明

SMC5 Antibody (YA7005) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SMC5.

Host

Rabbit

Clonality

Recombinant,Monoclonal

分子量

Predicted band size: 129 kDa;

Observed band size: 129 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat, Monkey

SwissProt ID

Q8IY18

Immunogen

Recombinant protein within human SMC5 aa 901-1,101.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:5000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200

Sensitivity	Endogenous	純度	Protein A affinity purified.
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541)

Subcellular Localization：Nucleus,Chromosome,Nucleus, PML body,Chromosome, telomere

Expression：
Tissue_Specificity: Widely expressed (PubMed:11408570). Strongly expressed in testis (PubMed:11408570)

Subunit：Forms a heterodimer with SMC6 (PubMed:11408570)

Synonyms

hSMC 5 antibody; hSMC5 antibody; KIAA0594 antibody; MLZ-453 antibody; OTTHUMP00000063367 antibody; SMC 5 antibody; SMC 5 structural maintenance of chromosomes 5 like 1 antibody; SMC protein 5 antibody; SMC-5 antibody; smc5 antibody

ドキュメンテーション

Select Batch:

データシート (231 KB) SDS (252 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

SMC5 Antibody (YA7005) 関連分類

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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SMC5 Antibody (YA7005)

Product Detail

Background

説明

SMC5 Antibody (YA7005) 関連分類

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