Snk Antibody (YA8978)
(Synonyms: SNK, PLK2, Serine/threonine-protein kinase PLK2, Polo-like kinase 2, Serine/threonine-protein kinase SNK, Serum-inducible kinase, PLK-2, hPlk2, hSNK)Snk Antibody (YA8978) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Snk.
-
Host:
Mouse
-
Isotype:
IgG
-
Application:
WB, ICC/IF, IF-Tissue, IP, ELISA
-
Reactivity :
human
-
Formulation:
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
|
IP
IP: Immunoprecipitation
|
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
|
|---|---|---|---|---|---|
| Dilution Ratio | 1:100-1000 | 1:50-500 | 1:50-500 | 1-2μg per 100-500μg Total protein | 1:30-3000 |
Product Details
Snk Antibody (YA8978) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Snk.
-
Host Mouse
-
Species Reactivityhuman
-
Calculated Molecular Weight Predicted band size: 78 kDa
OMIM: 607023
A synthesized peptide derived from human Snk.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
-
Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
-
Storage & Stability
Stored at 2-8°C for 1 year, do not freeze.
-
Shipping
Shipping with blue ice.
Background
-
Function
Snk is a Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CPAP, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CPAP and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress
-
Subcellular Localization
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole; Cell projection, dendrite
-
Expression
Tissue_Specificity: Expressed at higher level in the fetal lung, kidney, spleen and heart.
Induction: Directly regulated by p53/TP53. Negatively regulated by miR-126. -
Isoforms & Post-Translational Modification
Snk has 2 isoforms, Q9NYY3-1: amino acid length is 685, molecular weight is 78237 Da (predicted); Q9NYY3-2: amino acid length is 671, molecular weight is 76651 Da (predicted).
Catalytic activity is enhanced by phosphorylation of Thr-239 -
Subunit
Interacts with NSF; causing NSF dissociation from GRIA2.
-
SwissProt ID
-
Synonyms
SNK, PLK2, Serine/threonine-protein kinase PLK2, Polo-like kinase 2, Serine/threonine-protein kinase SNK, Serum-inducible kinase, PLK-2, hPlk2, hSNK
Documentation
Powered by Bioz
