SOX10 Antibody (YA4110)
(Synonyms: DOM; WS4; PCWH; WS2E; WS4C)SOX10 Antibody (YA4110) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SOX10.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:10000 |
Product Details
SOX10 Antibody (YA4110) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SOX10.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 60-80 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 49 kDa
Purified recombinant fragment of human SOX10 (AA: 147-252) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SOX10 transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3. Transcriptional activator of MBP, via binding to the gene promoter[1].
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Subcellular Localization
Cytoplasm; Nucleus; Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side
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Expression
Tissue_specificity:It is expressed in the fetal brain, as well as in the human brain, heart, small intestine, and colon. -
Isoforms & Post-Translational Modification
P56693 has 2 isomers: P56693-1: 49911 Da (predicted); P56693-2: 31088 Da (predicted).
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Subunit
Monomer. Interacts with ARMCX3 at the mitochondrial outer membrane surface. Interacts with PAX3 (PubMed:21965087)
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SwissProt ID
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Synonyms
DOM; WS4; PCWH; WS2E; WS4C
Documentation
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