SOX10 Antibody (YA5581)

Cat. No.: HY-P85889: Ficha de datos User Guide for Antibodies
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SOX10 Antibody (YA5581) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SOX10.

Para uso exclusivo en investigación. No vendemos a pacientes.

Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

SOX10 Antibody (YA5581) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SOX10.

Host

Mouse

Clonality

Monoclonal

Peso molecular

Predicted band size: 49 kDa;

Observed band size: 60 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P56693

Gene ID

6663 [NCBI]

Immunogen

Synthesized peptide derived from human protein AA range:1-100

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-2000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-500
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:1000-5000

Pureza	Protein G	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087). Transcriptional activator of MBP, via binding to the gene promoter (By similarity)

Subcellular Localization：Cytoplasm; Nucleus; Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side

Expression：
Tissue_specificity:It is expressed in the fetal brain, as well as in the human brain, heart, small intestine, and colon.

Isoforms & Post-Translational Modification：P56693 has 2 isomers: P56693-1: 49911 Da (predicted); P56693-2: 31088 Da (predicted).

Subunit：Monomer. Interacts with ARMCX3 at the mitochondrial outer membrane surface. Interacts with PAX3 (PubMed:21965087)

Synonyms

DOM; WS4; PCWH; WS2E; WS4C; SOX-10

Documentación

User Guide for Antibodies (1077 KB)