SOX6 Antibody
(Synonyms: Sox-6, Sox6, Transcription factor SOX-6, SOX-LZ)SOX6 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to SOX6.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ChIP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ChIP
ChIP: Chromatin Immunoprecipitation
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|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | Use at an assay dependent concentration |
Product Details
SOX6 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to SOX6.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 110 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 88; 89; 91 kDa
Synthetic peptide corresponding to the N-term region of human SOX6.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SOX6 is a Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity)
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Subcellular Localization
Nucleus; Cytoplasm
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Expression
Tissue_Specificity: Expressed in a wide variety of tissues, most abundantly in skeletal musclen. -
Isoforms & Post-Translational Modification
SOX6 has 4 isoforms, P35712-1: amino acid length is 828, molecular weight is 91921 Da (predicted); P35712-2: amino acid length is 804, molecular weight is 89332 Da (predicted); P35712-3: amino acid length is 808, molecular weight is 89735 Da (predicted); P35712-4: amino acid length is 801, molecular weight is 88988 Da (predicted).Sumoylation inhibits the transcriptional activity
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Subunit
Homodimer (By similarity).
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SwissProt ID
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Synonyms
Sox-6, Sox6, Transcription factor SOX-6, SOX-LZ
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