SYK Antibody (YA5071)(PBS only)
(Synonyms: SLC22A1; OCT1; Solute carrier family 22 member 1; Organic cation transporter 1; hOCT1)SYK Antibody (YA5071) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SYK.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:10000 |
Product Details
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Syk (Spleen tyrosine kinase) is a cytosolic non-receptor protein tyrosine kinase (PTK) that is expressed at high levels, both in hematopoietic cells (such as mast cells, B lymphocytes, T lymphocytes, neutrophils, dendritic cells, and macrophages) and in non-hematopoietic cells.
Syk mediates key signal transduction pathways following the activation of immune cell receptors. Syk associates with different receptors on the surface of various cells such as B cells, mast cells, monocytes, macrophages, and neutrophils, and even osteoclasts and breast cancer cells. Following the engagement of these receptors with their ligands, SYK is activated and orchestrates diverse cellular responses, including cytokine production (in T cells and monocytes) and phagocytosis (in macrophages) .
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Subcellular Localization
Basolateral cell membrane; Multi-pass membrane protein; Apical cell membrane; Multi-pass membrane protein; Lateral cell membrane; Multi-pass membrane protein; Basal cell membrane; Multi-pass membrane protein; Cell membrane; Multi-pass membrane protein
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Expression
Tissue_specificity:It is widely expressed in the liver at high levels (PubMed:11388889, PubMed:23680637, PubMed:9187257, PubMed:9260930) . In the liver, it is mainly expressed around the central vein (PubMed:16263091) . It is also expressed in the kidneys (PubMed:9187257, PubMed:9260930) . It is also expressed in enterocytes of the small intestine (PubMed:16263091, PubMed:23680637) . In the testes, it is mainly located in peritubular myoid cells and Leydig cells, and moderately expressed in the basement membrane of Sertoli cells (PubMed:35307651) . It is also expressed in the ciliated epithelium of the trachea and bronchi in the respiratory tract (PubMed:15817714) . It is also expressed in skeletal muscle, stomach, spleen, heart, placenta, colon, brain, granulocytes, and lymphocytes (PubMed:9187257, PubMed:9260930) ; expressed in the liver and glial cell lines; expressed in the liver and glial cell lines; expressed in glial cell lines. Not expressed in the liver; expressed in glial cell lines. Not expressed in the liver.
Induction:In the liver activated by HNF4A and suppressed by bile acids via NR0B2. Increased by cholesterol treatment in hepatocyte cells -
Isoforms & Post-Translational Modification
O15245 has 4 isomers: O15245-1: 61154 Da (predicted); O15245-2: 56094 Da (predicted); O15245-3: 53593 Da (predicted); O15245-4: 39224 Da (predicted).
Phosphorylated -
SwissProt ID
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Synonyms
SLC22A1; OCT1; Solute carrier family 22 member 1; Organic cation transporter 1; hOCT1
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