country

Change Language

Country or Region:

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-P85816

TBR1 Antibody (YA5508)

Name: TBR1 Antibody (YA5508)
Brand: MedChemExpress
SKU: HY-P85816
Availability: PreOrder

TBR1 Antibody (YA5508) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to TBR1.

For research use only. We do not sell to patients.

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	ELISA ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio	1:500-2000	1:100-500	1:1000-5000

Description

TBR1 Antibody (YA5508) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to TBR1.

Host Mouse
Clonality Monoclonal
Species Reactivity
Human, Mouse, Rat
Observed Molecular Weight

Observed band size: 74 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 74 kDa

Immunogen

AA range: 1-682

Purification

affinity chromatography.

Conjugation

Non-conjugated

Modification

Unmodified

Appearance

Liquid
Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

TBR1 transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection. As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons^[1]^[2].
Subcellular Localization

Nucleus
Expression

Tissue_specificity:brain
Isoforms & Post-Translational Modification

Q16650 has 2 isomers: Q16650-1: 74053 Da (predicted); Q16650-2: 42332 Da (predicted).
Subunit

Homodimer (PubMed:25232744). Part of a complex containing CASK, TBR1 and TSPYL2; may modulate gene expression in response to neuronal synaptic activity (By similarity). Interacts with FOXP2 (PubMed:25232744, PubMed:30250039). Interacts with FOXP1 (PubMed:30250039). Interacts with BCL11A (PubMed:30250039)
SwissProt ID

Q16650
Gene ID

10716 [NCBI]