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TBX5 Antibody (YA5076)(PBS only)

(Synonyms: TBX5; T-box transcription factor TBX5; T-box protein 5)

TBX5 Antibody (YA5076) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to TBX5.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    WB

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • TBX5 Antibody (YA5076)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:500-1:1000

Product Details

Description

TBX5 Antibody (YA5076) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to TBX5.

  • Host Mouse
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 53 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 58 kDa
Immunogen

Purified recombinant fragment of TBX5 expressed in E. Coli. The exact sequence is proprietary to MCE.

Purification

Ascitic Fluid

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    TBX5 is a DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. Binds to the core DNA motif of NPPA promoter[1][2][3][4][5][6][7].

  • Subcellular Localization

    Nucleus; Cytoplasm

  • Isoforms & Post-Translational Modification

    Q99593 has 3 isomers: Q99593-1: 57711 Da (predicted); Q99593-2: 39196 Da (predicted); Q99593-3: 52659 Da (predicted).
    Acetylation at Lys-339 by KAT2A and KAT2B promotes nuclear retention

  • Subunit

    Monomer (PubMed:20450920). Homodimer (via the T-box); binds DNA as homodimer (PubMed:26926761). Interacts (via the T-box) with NKX2-5 (via the homeobox); this complex binds DNA (PubMed:26926761).

  • SwissProt ID

    Q99593

  • Gene ID
    6910 [NCBI]
  • Synonyms

    TBX5; T-box transcription factor TBX5; T-box protein 5

TBX5 Antibody (YA5076)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • TBX5 Antibody (YA5076)(PBS only) Product Image