Copy Link Print Information

TCF7 Antibody (YA5900)

(Synonyms: TCF7; TCF1; Transcription factor 7; TCF-7; T-cell-specific transcription factor 1; T-cell factor 1; TCF-1)
Customer Review

Based on 1 Customer Validation

TCF7 Antibody (YA5900) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TCF7.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG/Kappa

  • Application:

    WB, IHC-P, ICC/IF, ELISA

  • Reactivity :

    Human, Rat

  • Formulation:

    Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

  • Conjugation:
    Non-conjugated
  • TCF7 Antibody (YA5900) Product Image
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Service
Data Download
Related Products:
Top Publications Citing

Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:1000-1:4000 1:2000-1:10000 1:200-1:1000 1:5000-1:20000

Product Details

Description

TCF7 Antibody (YA5900) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TCF7.

  • Host Rabbit
  • Clonality Monoclonal
  • Species Reactivity
    Human, Rat
  • Observed Molecular Weight
    Observed band size: 60 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 42 kDa
Purification

Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG/Kappa

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    TCF7 transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages. Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes

  • Subcellular Localization

    Nucleus

  • Expression


    Tissue_specificity:It is primarily expressed in T cells. It can also be detected in proliferating intestinal epithelial cells and basal cells of the mammary epithelium.

    Induction:By TCF7L2 and CTNNB1

  • Isoforms & Post-Translational Modification

    P36402 has 15 isomers: P36402-5: 41552 Da (predicted); P36402-1: 41642 Da (predicted); P36402-2: 30264 Da (predicted); P36402-3: 51991 Da (predicted); P36402-9: 39681 Da (predicted); P36402-10: 28304 Da (predicted); P36402-13: 39933 Da (predicted); P36402-14: 28556 Da (predicted); P36402-15: 40418 Da (predicted); P36402-16: 29041 Da (predicted); P36402-6: 30175 Da (predicted); P36402-7: 41668 Da (predicted); P36402-8: 30291 Da (predicted); P36402-17: 40614 Da (predicted); P36402-18: 44828 Da (predicted).

  • Subunit

    Binds the armadillo repeat of CTNNB1 and forms a stable complex (PubMed:9488439, PubMed:9783587). Interacts with TLE5, TLE1, TLE2, TLE3 and TLE4 (PubMed:11266540, PubMed:9783587). Interacts with MLLT11 (PubMed:26079538). Long isoform interacts (via N-terminus) with SOX13; inhibits WNT-mediated transcriptional activity (PubMed:17218525, PubMed:20028982). Interacts with DAZAP2 (PubMed:19304756)

  • SwissProt ID

    P36402

  • Gene ID
    6932 [NCBI]
  • Synonyms

    TCF7; TCF1; Transcription factor 7; TCF-7; T-cell-specific transcription factor 1; T-cell factor 1; TCF-1

TCF7 Antibody (YA5900) Related Classifications

MOQ
Minimum order quantity
100 mg

Get Quote In-stock

Other size
Get Quote
Please select quantity
Amount: USD 0.00

Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • TCF7 Antibody (YA5900) Product Image
    1/16
  • TCF7 Antibody (YA5900) Product Image