Transcription Factor AP 2 gamma Antibody (YA4399)
(Synonyms: ERF1; TFAP2G; hAP-2g; AP2-GAMMA)Transcription Factor AP 2 gamma Antibody (YA4399) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Transcription Factor AP 2 gamma.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:10000 |
Product Details
Transcription Factor AP 2 gamma Antibody (YA4399) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Transcription Factor AP 2 gamma.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 49 kDa
Purified recombinant fragment of human TFAP2C (AA: 341-450) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Transcription Factor AP 2 gamma is a Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions. TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation. At the 8-cell stage, during morula development, controls expression of cell-polarity genes. Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2. Binds to both closed and open chromatin with other transcription factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer[1][2].
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Subcellular Localization
Nucleus
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Expression
Induction:During retinoic acid-mediated differentiation -
Isoforms & Post-Translational Modification
Q92754 has 2 isomers: Q92754-1: 49177 Da (predicted); Q92754-2: 31010 Da (predicted).
Sumoylated on Lys-10; which inhibits transcriptional activity -
Subunit
Binds DNA as a dimer (PubMed:11694877). Can form homodimers or heterodimers with other AP-2 family members (PubMed:11694877). Interacts with WWOX (PubMed:15548692). Interacts with UBE2I (PubMed:12072434). Interacts with KCTD1; this interaction represses transcription activation (PubMed:19115315). Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity (PubMed:11694877, PubMed:12586840). Interacts with CITED4 (PubMed:11744733). Interacts with MTA1 (PubMed:24413532)
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SwissProt ID
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Synonyms
ERF1; TFAP2G; hAP-2g; AP2-GAMMA
Documentation
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