TFAP2C - transcription factor AP-2 gamma Gene

Also Known as ERF1; TFAP2G; hAP-2g; AP2-GAMMA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7022

About TFAP2C

Cytogenetic location: 20q13.31 Genomic coordinates (GRCh38): 20:56,629,306-56,639,283 (from NCBI)

This gene has 2 transcripts (splice variants), 217 orthologues and 4 paralogues. Biased expression in skin (RPKM 24.1), placenta (RPKM 10.9) and 6 other tissues.

Summary

The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with Other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008]

TFAP2C Products (1)

mRNA Protein Name
NM_003222.4 NP_003213.1 transcription factor AP-2 gamma

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
12072434 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11278550 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11278550 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
24413532 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11694877 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in male gonad development IEP
IEP: Inferred from expression pattern
17848411 GOA
involved in negative regulation of gene expression, epigenetic IMP
IMP: Inferred from mutant phenotype
24413532 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
22735262 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
24413532 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TFAP2C Protein Structure

TF_AP-2

TF_AP-2: Transcription factor AP-2 (220 - 427)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 450 a.a.
Protein Preferred Names Protein Names

transcription factor AP-2 gamma

  • activating enhancer-binding protein 2 gamma

TFAP2C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TFAP2C Q92754 UBE2I Homo sapiens P63279
Y2H
12072434
Intra
TFAP2C Q92754 UBE2I Homo sapiens P63279
Pull Down
24835590
Intra
TFAP2C Q92754 UBE2I Homo sapiens P63279
Anti Tag CoIP
24835590
Intra
TFAP2C Q92754 CITED2 Homo sapiens Q99967
Y2H
12586840
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TFAP2C Proteins

Cat. No. Product Name Accession Purity
HY-P76728 AP-2 gamma/TFAP2C Protein, Human (His) Q92754-1 (L128-V223) ≥ 95%, as determined by reducing SDS-PAGE.

TFAP2C Antibodies

Cat. No. Product Name Application Reactivity
HY-P81397 Transcription Factor AP 2 gamma Antibody (YA1142) IHC-P Human
HY-P81397A Transcription Factor AP 2 gamma Antibody (YA1142)(PBS only) IHC-P Human
HY-P84702 Transcription Factor AP 2 gamma Antibody (YA4399) WB, IHC-P, ELISA Human
HY-P84702A Transcription Factor AP 2 gamma Antibody (YA4399)(PBS only) WB, IHC-P, ELISA Human

Related Diseases

Diseases Alias
Extragonadal Seminoma

  • Primary Extragonadal Seminoma
Char Syndrome

  • Patent Ductus Arteriosus With Facial Dysmorphism And Abnormal Fifth Digits

  • CHAR
Seminoma

  • Seminoma, Pure
Branchiooculofacial Syndrome

  • Branchio-Oculo-Facial Syndrome

  • BOFS

  • Bof Syndrome

  • Hemangiomatous Branchial Clefts-Lip Pseudocleft Syndrome

  • Lip Pseudocleft-Hemangiomatous Branchial Cyst Syndrome

  • Branchial Clefts With Characteristic Facies, Growth Retardation, Imperforate Nasolacrimal Duct, And Premature Aging

  • Branchial Clefts With Characteristic Facies Growth Retardation Imperforate Nasolacrimal Duct And Premature Aging

  • Bofs Syndrome

  • Lip Pseudocleft-Hemagiomatous Branchial Cyst Syndrome
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Brain Germinoma

  • Intracranial Germinoma

  • Germinoma Of The Brain
Spermatocytoma

  • Spermatocytic Seminoma
Childhood Germ Cell Cancer

  • Pediatric Germ Cell Tumor

  • Paediatric Germ Cell Cancer

  • Paediatric Germ Cell Neoplasm

  • Pediatric Germ Cell Cancer

  • Pediatric Germ Cell Neoplasm
Testicular Germ Cell Cancer

  • Germ Cell Tumor Of Testis

  • Testicular Germ Cell Tumor

  • Testicular Germ Cell Neoplasm

  • Testicular Malignant Germ Cell Tumor
Patent Ductus Arteriosus 1

  • Patent Ductus Arteriosus

  • PDA1

  • Pda

  • Ductus Arteriosus, Patent

  • Patent Ductus Arteriosus, Susceptibility To

  • Patent Ductus Botalli

  • Patency Of The Ductus Arteriosus

  • Patent Ductus Arteriosus Familial

  • Ductus Arteriosus Patent

  • Patent Ductus Arteriosus - Persisting Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14410 TFAP2C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17859 Tfap2c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24328 Tfap2c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TFAP2C VGNC VGNC:47285
Bos taurus TFAP2C VGNC VGNC:35778
Rattus norvegicus TFAP2C RGD RGD:1303185
Mus musculus TFAP2C MGD MGI:106032
Macaca mulatta TFAP2C VGNC VGNC:78322
Felis catus TFAP2C VGNC VGNC:66110
Others TFAP2C NCBI