Transcription Factor AP 2 gamma Antibody (YA1142)
(Synonyms: ERF1; TFAP2G; hAP-2g; AP2-GAMMA)Transcription Factor AP 2 gamma Antibody (YA1142) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transcription Factor AP 2 gamma.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.213.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:100-1:200 |
Product Details
Transcription Factor AP 2 gamma Antibody (YA1142) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transcription Factor AP 2 gamma.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 48 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 49 kDa
Recombinant protein of human AP2 gamma
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.213.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Transcription Factor AP 2 gamma is a Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions. TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation. At the 8-cell stage, during morula development, controls expression of cell-polarity genes. Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2. Binds to both closed and open chromatin with other transcription factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer[1][2].
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Subcellular Localization
Nucleus
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Expression
Induction:During retinoic acid-mediated differentiation -
Isoforms & Post-Translational Modification
Q92754 has 2 isomers: Q92754-1: 49177 Da (predicted); Q92754-2: 31010 Da (predicted).
Sumoylated on Lys-10; which inhibits transcriptional activity -
Subunit
Binds DNA as a dimer (PubMed:11694877). Can form homodimers or heterodimers with other AP-2 family members (PubMed:11694877). Interacts with WWOX (PubMed:15548692). Interacts with UBE2I (PubMed:12072434). Interacts with KCTD1; this interaction represses transcription activation (PubMed:19115315). Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity (PubMed:11694877, PubMed:12586840). Interacts with CITED4 (PubMed:11744733). Interacts with MTA1 (PubMed:24413532)
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SwissProt ID
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Synonyms
ERF1; TFAP2G; hAP-2g; AP2-GAMMA
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Research Field
Cell Biology
Documentation
References
[1]. Bamforth SD, et al. Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. Nat Genet. 2001 Dec;29(4):469-74. [Content Brief]
[2]. Kang HJ, et al. Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1. Cancer Res. 2014 Mar 1;74(5):1484-94. [Content Brief]
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