TFDP1 Antibody
(Synonyms: DP1, TFDP1, Transcription factor Dp-1, DRTF1-polypeptide 1, E2F dimerization partner 1, DRTF1)TFDP1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to TFDP1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:100-500 |
Product Details
TFDP1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to TFDP1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 52 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 45 kDa
Synthetic peptide corresponding to the C-term region of human TFDP1.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TFDP1 is a Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters[1][2][3].
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Subcellular Localization
Nucleus; Cytoplasm
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Expression
Tissue_Specificity: Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lung and pancreas. Not detected in heart.
Induction: Down-regulated during differentiation. -
Isoforms & Post-Translational Modification
TFDP1 has 2 isoforms, Q14186-1: amino acid length is 410, molecular weight is 45070 Da (predicted); Q14186-2: amino acid length is 311, molecular weight is 34921 Da (predicted).
Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation. -
Subunit
Component of the E2F:DP transcription factor complex.
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SwissProt ID
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Synonyms
DP1, TFDP1, Transcription factor Dp-1, DRTF1-polypeptide 1, E2F dimerization partner 1, DRTF1
Documentation
[1]. Wu CL, et al. In vivo association of E2F and DP family proteins. Mol Cell Biol. 1995 May;15(5):2536-46. [Content Brief]
[2]. Helin K, et al. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes Dev. 1993 Oct;7(10):1850-61. [Content Brief]
[3]. Zaragoza K, et al. Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. Mol Cell Biol. 2010 May;30(9):2293-304. [Content Brief]
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