TGFBR3 Antibody (YA4173)(PBS only)
(Synonyms: BGCAN; betaglycan)TGFBR3 Antibody (YA4173) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TGFBR3.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
WB, ELISA
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:10000 |
Product Details
TGFBR3 Antibody (YA4173) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TGFBR3.
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Host Mouse
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 93 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 93 kDa
Purified recombinant fragment of human TGFBR3 (AA: 147-328 ) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TGFBR3 cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis. Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5. Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking. Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin. By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B. In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility. Plays a role in the inhibition of directed and random cell migration in epithelial cells by altering the actin cytoskeletal organization. Participates in epithelial-mesenchymal transformation (EMT) upon binding to BMP2 or TGFB2, by activating the PAR6/SMURF1/RHOA pathway; (Microbial infection) May act as a receptor for human cytomegalovirus in different cell types by interacting with HCMV trimer composed of GO, GH and GL[1][2][3][4][5][6].
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Secreted; Secreted, extracellular space, extracellular matrix
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Isoforms & Post-Translational Modification
Q03167 has 2 isomers: Q03167-1: 93499 Da (predicted); Q03167-2: 93428 Da (predicted).
Extensively modified by glycosaminoglycan groups (GAG);Phosphorylated in the cytoplasmic domain by the type II receptor TGFBR2 at THR-840 to mediate recruitment of ARRB2 and subsequent internalization of TGFBR2 and TGFBR3 -
Subunit
Forms homodimers and homooligomers (PubMed:11323414). Interacts with DYNLT4 (PubMed:16982625). Interacts with integrin ITGA5:ITGB1; this interaction promotes the internalization and trafficking of ITGA5:ITGB1 into endocytic vesicles (PubMed:22562249). Interacts with TGFB1, BMP2, BMP5, BMP7 or GDF5 and inhibin A via the ligand binding domains (PubMed:18184661). Interacts with ALK3/BMPR1A; this interaction results in the cell surface retention of BMPR1A (PubMed:19726563). Interacts with ALK6/BMPR1B; this interaction enhances BMPR1B-mediated stimulation of the BMP signaling pathway (PubMed:19726563). Interacts with the scaffolding protein beta-arrestin2/ARRB2; this interaction mediates internalization of TGFBR3 and thus regulates migration, actin cytoskeleton and activation of CDC42 (PubMed:12958365, PubMed:18184661, PubMed:19416857, PubMed:19325136)
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SwissProt ID
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Synonyms
BGCAN; betaglycan
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