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Cat. No.: HY-P87637

Thrombomodulin Antibody (YA7321)

Thrombomodulin Antibody (YA7321) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Thrombomodulin.

For research use only. We do not sell to patients.

Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

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Stock

Quantity

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	IHC-P IHC-P: Immunohistochemistry-Paraffin	IHC-F IHC-F: Immunohistochemistry-Frozen	IF-Tissue IF-Tissue: Immunofluorescence-Tissue	FC FC: Flow Cytometry
Dilution Ratio	1:500-2000	1:100-500	1:100-500	1:100-500	1:50-100

Description

Thrombomodulin Antibody (YA7321) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Thrombomodulin.

Host Rabbit
Clonality Recombinant,Monoclonal
Species Reactivity
Mouse
Observed Molecular Weight

Observed band size: 105,70 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 62 kDa

Immunogen

A synthesized peptide derived from mouse Thrombomodulin

Sensitivity

Endogenous

Purification

affinity purified by Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Appearance

Liquid
Formulation

Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

Thrombomodulin is an Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis. Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway. Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or anaphylatoxins leading to fibrinolysis inhibition. Plays critical protective roles in changing the cleavage specificity of protease-activated receptor 1/PAR1, inhibiting endothelial cell permeability and inflammation. Suppresses inflammation distinctly from its anticoagulant cofactor activity by sequestering HMGB1 thereby preventing it from engaging cellular receptors such as RAGE and contributing to the inflammatory response^[1].
Subcellular Localization

Membrane
Expression

Tissue_Specificity: Endothelial cells are unique in synthesizing thrombomodulin
Isoforms & Post-Translational Modification

P15306: 577 amino acids, molecular weight 61868 Da.
Subunit

Interacts with ITGAL, ITGAM and ITGB2
SwissProt ID

P15306