Thrombomodulin Antibody (YA892)
(Synonyms: CD141; Fetomodulin; THBD; THRM; thrombomodulin; TM)Thrombomodulin Antibody (YA892) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Thrombomodulin.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB
-
Reactivity :
Mouse, Rat
-
Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
Thrombomodulin Antibody (YA892) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Thrombomodulin.
-
Host Rabbit
-
Clonality Recombinant,Monoclonal
-
Species ReactivityMouse, Rat
-
Observed Molecular WeightObserved band size: 95 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 62 kDa
Entrez Gene: 21824 Mouse ; 83580 Rat
SwissProt: P15306 Mouse ;
Recombinant protein of mouse Thrombomodulin
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
Thrombomodulin is an Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis. Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway. Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or anaphylatoxins leading to fibrinolysis inhibition. Plays critical protective roles in changing the cleavage specificity of protease-activated receptor 1/PAR1, inhibiting endothelial cell permeability and inflammation. Suppresses inflammation distinctly from its anticoagulant cofactor activity by sequestering HMGB1 thereby preventing it from engaging cellular receptors such as RAGE and contributing to the inflammatory response[1].
-
Subcellular Localization
Membrane; Single-pass type I membrane protein
-
Expression
Tissue_specificity:Endothelial cells are unique in synthesizing thrombomodulin -
Subunit
Interacts with ITGAL, ITGAM and ITGB2. Interacts with thrombin/F2; this interaction switches the specificity of thrombin from a procoagulant to an anticoagulant and antifibrinolytic protease. Interacts with ANGP1 and ANGP2; these interactions significantly inhibit the generation of activated PC and TAFIa/CPB2 by the thrombin/thrombomodulin complex. Interacts with PF4; this interaction enhances generation of activated protein C. Interacts with HMGB1; this interaction inhibits HMGB1 inflammatory activity
-
SwissProt ID
-
Synonyms
CD141; Fetomodulin; THBD; THRM; thrombomodulin; TM
-
Research Field
Cardiovascular
Documentation
Powered by Bioz
