TIAM2 Antibody (YA7559)
(Synonyms: KIAA2016, STEF, TIAM2, Rho guanine nucleotide exchange factor TIAM2, SIF and TIAM1-like exchange factor, T-lymphoma invasion and metastasis-inducing protein 2, TIAM-2)
Based on 1 Customer Validation
TIAM2 Antibody (YA7559) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to TIAM2.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, IHC-P, ICC/IF, ELISA
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
|
|---|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:2000-1:10000 | 1:200-1:1000 | 1:5000-1:20000 |
Product Details
TIAM2 Antibody (YA7559) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to TIAM2.
-
Host Rabbit
-
Clonality Monoclonal,Recombinant
-
Species ReactivityHuman, Mouse, Rat
-
Observed Molecular WeightObserved band size: 187 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 187 kDa
The exact sequence is proprietary to MCE.
Endogenous
Protein A affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA.
-
Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
TIAM2 modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. Activates specifically RAC1, but not CDC42 and RHOA
-
Subcellular Localization
Cytoplasm,Cell projection, lamellipodium,Cell projection, filopodium,Cell projection, growth cone,Cell projection, neuron projection,Perikaryon
-
Expression
Tissue_Specificity: Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis -
Isoforms & Post-Translational Modification
Q8IVF5 has 5 isomers: Q8IVF5-1: 190103 Da (predicted); Q8IVF5-2: 193398 Da (predicted); Q8IVF5-3: 70774 Da (predicted); Q8IVF5-4: 114079 Da (predicted); Q8IVF5-5: 192555 Da (predicted).
Phosphorylated on serine and threonine residues -
Subunit
Interacts with MAP1A, MAP1B, PARP1 and YWHAE
-
SwissProt ID
-
Synonyms
KIAA2016, STEF, TIAM2, Rho guanine nucleotide exchange factor TIAM2, SIF and TIAM1-like exchange factor, T-lymphoma invasion and metastasis-inducing protein 2, TIAM-2
Documentation
Powered by Bioz
